黄芪皂甙对大鼠MCAO/IR模型氨基酸含量的影响──活体微透析研究  

Effects of Astrasieversianin on Extracellular Amino Acid Changes of Rat MCAO/IR Model-An in vivo Micodialysis Study

作　　者：陈国俊[1,2,3,4] 秦震[1,2,3,4] 陈毓群 李晓燕 高慧[1,2,3,4] 

机构地区：[1]上海医科大学神经病学研究所 [2]中山医科大学附一院神经内科 [3]中科院上海有机化学研究所 [4]上海医科大学神经生物国家重点实验室

出　　处：《临床神经病学杂志》1998年第2期67-70,共4页Journal of Clinical Neurology

摘　　要：采用大鼠插线法缺血１小时再灌流２小时模型，比较对照组和黄芪皂甙（ＡＳＳ）组在缺血／再灌流时氨基酸和含水量的变化。结果：（１）脑缺血６０分钟时上升到峰值浓度，随后很快下降，再灌流２小时内未见回升；（２）ＡＳＳ组谷氨酸（Ｇｌｕ）峰值浓度下降了１３．２％，但未见统计学差异；（３）黄芪皂甙显著降低了梗塞灶内脑组织含水量。认为尽管ＡＳＳ未能使Ｇｌｕ产生明显下降，但能降低梗塞灶含水量，说明ＡＳＳ的脑保护作用可能是通过其它途径实现的。Using a rat model of middle cerebral artery occlusion and reperfusion(MCAO/IR),we compared amino acids with water content changes in controls and ASS treated groups.The results demanstrated that (1) In control group,amino acids increased at a peak level after 60 minutes of ischemia followed by a rapid decrease, during reperfusion,there were not any increase of them;(2) In ASS group, glutamate peak level decreased 13.2 per cent, but failed to show statistics changes;(3)ASS lowered water content in the ischemic area.It indicated that although ASS failed to decrease glutamate peak level ,it can decrease water content in ischemic area, ASS may exert its protection role by other mechanisms.

关 键 词：黄芪皂甙 脑缺血再灌流 兴奋性氨基酸 

分 类 号：R971.9[医药卫生—药品] R965.2[医药卫生—药学]