5-硝基水杨酸的制备  

Preparation of 5-Nitrosalicylic Acid

作　　者：朱惠琴[1] 

机构地区：[1]淮阴师范学院化学系,江苏淮安223300

出　　处：《中国医药工业杂志》2009年第4期260-260,共1页Chinese Journal of Pharmaceuticals

摘　　要：5-硝基水杨酸(1)是抗溃疡性结肠炎药物美沙拉秦(mesalazine)的原料,也可用于制备偶氮染料和有机合成。大多以水杨酸直接硝化制备:5-Nitrosalicylic acid was prepared by the nitration of salicylic acid in acetic acid with ceric ammonium nitrate as the nitrating agent, and with PEG-400 as the phase transfer catalyst under microwave irradiation with a yield of 70%.

关 键 词：5-硝基水杨酸 结肠炎 美沙拉秦 有机合成 

分 类 号：TQ246.16[化学工程—有机化工]