银杏叶提取物治疗冠心病的机制研究  

Therapeutic Mechanisms of Ginkgo Biloba Extract on Coronary Artery Disease

作　　者：武宇洲[1] 孙晓红[2] 李淑琴[3] 祖秀光[1] 都军[1] 王凤飞[1] 

机构地区：[1]河北医科大学第二医院,河北石家庄050000 [2]河北省人民医院,河北石家庄050051 [3]河北医科大学,河北石家庄050017

出　　处：《四川中医》2009年第4期45-47,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：河北省科技攻关项目(99276129D);河北省科学技术研究与发展指导计划(07276450);河北省医学科学研究重点课题计划项目(08064);河北省中医药管理局科学技术研究课题计划项目(2008126)

摘　　要：目的:研究银杏叶提取物治疗冠心病的机制。方法:将100例冠心病患者随机分为银杏叶提取物治疗组和对照组,观察心绞痛症状,检测冠状动脉左前降支(LAD)血流,血浆一氧化氮(NO)和内皮素(ET)水平。结果:治疗组的总有效率优于对照组(P<0.01),并且LAD舒张期峰值流速,收缩期峰值流速和舒张期时间速度积分显著增加(P<0.01),NO水平升高(P<0.01),ET水平下降(P<0.01),NO/ET比值升高(P<0.01);而对照组LAD血流,NO和ET水平无明显变化。Pearson线性相关分析显示,LAD血流的增加与血浆NO水平升高,ET水平下降,以及NO/ET比值升高显著相关(P<0.05)。结论:银杏叶提取物可增加冠心病患者LAD血流,其机制可能与改善血浆NO和ET平衡有关。Objective： To study the therapeutic mechanisms of Ginkgo biloba extract on coronary artery disease. Methods： One hun-dred patients with coronary artery disease were randomly assigned to treatmem group （treated with Ginkgo biloba extract injection） and control group. At baseline and after therapy, distal left anterior descending coronary artery （LAD） blood flow, plasma NO and ET con- centration were measured; Meanwhile, the symptoms of angina pectoris were observed. Results： Treatment group had higher effective rate than control group （P〈0.01） . Treatment with Ginkgo biloba extract demonstrated a significant improvement in diastolic peak velocity, systolic peak velocity and diastolic time velocity integral of LAD blood flow （P〈0.01）. In treatment group, plasma NO increased （P〈0.01）, ET decreased （P〈0.01）, and then NO/ET ratio was increased （P〈0.01） . In contrast, saline had no effects on these parameters. A linear correlation was confirmed between the percentage change in LAD blood flow and NO, ET or NO/ET ratio following Ginkgo biloba extract treatment. Conclusion： Ginkgo biloba extract in the treatment of coronary artery disease can in- crease LAD blood flow, which might be at least partly related to the restoration of delicate equilibrium between NO and ET.

关 键 词：银杏叶提取物 冠心病 一氧化氮 内皮素 冠脉血流显像 

分 类 号：R541.4[医药卫生—心血管疾病]