三花接骨散促进生长激素和骨折愈合的研究  

Study on the Mechenism of Rasise GH Level and Accelerrate in Bone Union with San-Hua Bone Connecting Powder

作　　者：柳海峰[1,2] 陈晋杰[1,2] 杨佩荪 张连柱[1,2] 董瑞安[1,2] 刘冬梅 王蓬文[1,2] 孟令文 

机构地区：[1]首都骨伤病研究所首都医科大学附属北京儿童医院 [2]首都医科大学病理教研组

出　　处：《中国中医骨伤科》1998年第2期7-11,共5页Chinese Journal of Traditional Medical Traumatology & Orthopedics

摘　　要：目的：了解三花接骨散使血清内生长激素（ＧＨ）的浓度变化与其促进骨折愈合的机理。方法：骨折后３、７、１４、２８日断头取血，用鼠生长激素放免试剂测定血清中ＧＨ浓度。同时取垂体称重量，石蜡包埋切片进行垂体ＧＨ免疫组化染色，测定ＧＨ细胞面积及ＧＨ细胞内激素含量。结果：服三花接骨散１４天的骨折组血清ＧＨ浓度和垂体ＧＨ细胞内激素含量均增高。结论：服药后血清ＧＨ增高可能是三花接骨散促进骨折愈合的原因之一。Objective:To understand the relationship between the level of serum growth hormone(GH) and the mechenism of acceleration of bone union with San-Hua bone connecting Powder.Methods:The level of serum GH was detected with GH radioimmunoessay of mouse,the blood specimen being obtain from head amputation with 3、7、14and 28 days after fracture.Meanwhile,being weigh the pituitary gland,tissue section with GH immunohistochemistry technique,to determine the cell area related with GH and the GH content within the GH cell.Results:The level of serum GH and the GH content within the GH cells of pituiary gland by 14 days after fracture with San-Hua bone connecting powder higher than the control.Conclusion:Serum is higher than the control.GH raising may be one of the causes of accelerating bone union effect of San-Hua bone Connecting Powder.

关 键 词：骨折愈合 生长激素 垂体 三花接骨散 药理 

分 类 号：R289.5[医药卫生—方剂学]