电针对慢性内脏痛敏大鼠痛反应的影响  

Effect of eletroacupuncture on rats with chronic visceral hyperalgesia

作　　者：刘庆[1] 刘翠英[1] 焦海霞[1] 陈瑜[1] 林春[1] 

机构地区：[1]福建省福州市福建医科大学基础医学院疼痛研究室,生理与病理生理学系,神经生物研究中心,350004

出　　处：《实用疼痛学杂志》2009年第1期9-12,共4页Pain Clinic Journal

基　　金：福建省自然科学基金资助（No.C0610022）;福建医科大学教授基金（No.JS07004）资助

摘　　要：目的观察电针对慢性内脏痛敏大鼠痛反应的影响，为临床电针治疗慢性内脏痛机制研究打下基础。方法对新生幼鼠给予结肠扩张刺激，造成其成年后慢性内脏痛觉敏化。对此内脏痛大鼠隔日电针1次共4次，观察其腹壁撤退反射评分，腹外斜肌放电幅值和甩尾反射潜伏期等指标变化。结果内脏痛大鼠与正常对照大鼠相比，腹壁撤退反射评分增高，肌电幅值明显增大，甩尾反射潜伏期明显缩短；内脏痛大鼠电针4次后上述3项指标与电针前相比，差异有统计学意义，而与正常对照大鼠之间差异无显著性。结论电针能明显改善慢性内脏痛大鼠的痛反应。Objective The effect of eletroacupuncture on rats with chronic visceral hyperalgesia was observed to provide basic knowledge about its mechanism. Methods Rats with chronic visceral hyperalgesia were generated by colorectal distensions during postnatal days 8-14. Electroacupuncture treatment was given every two days, four times in all in the hypersensitive rats. Scores of abdominal withdraw reflex（AWR）, electromyogram （EMG） of abdominal external oblique and tail flick latency （TFL） were observed. Results Compared with controls, AWR scores and EMG were significantly increased and TFL was significantly decreased in hypersensitive rats. After Electroacupuncture treatment, AWR score and EMG were significantly decreased, the TFL were significantly increased in hypersensitive rats. Conclusion Electroacupuncture can significantly improve the pain response in rats with chronic visceral hyperalgesia.

关 键 词：内脏 疼痛 慢性病 腹壁撤退反射 腹外斜肌放电 甩尾反射 电针 

分 类 号：R245.97[医药卫生—针灸推拿学] R441.1[医药卫生—中医临床基础]