腺苷钴胺联合阿昔洛韦治疗带状疱疹性神经痛疗效观察  

Clinical effect of cobamamide combined with acyclovir on neuralgia in patients with herpes zoster

作　　者：郝江华[1] 郗宁[1] 唐晓林[1] 

机构地区：[1]甘肃省兰州市甘肃省人民医院皮肤科,730000

出　　处：《实用疼痛学杂志》2009年第1期34-36,共3页Pain Clinic Journal

摘　　要：目的探讨腺苷钴胺联合阿昔洛韦治疗带状疱疹性神经痛的临床疗效。方法将60例患者随机分为治疗组和对照组，各30例。两组患者均口服阿昔洛韦0．2g，5次／d。治疗组加用腺苷钴胺肌注0．5mg，1次／d；对照组加用Vit B12肌注0．5mg，1次／d。两组均连续治疗7～21d。均于疗后1周、3周观察疗效。结果治疗后1周，治疗组、对照组总有效率分别为56．7％（17／30例）、43．3％（13／30例）；治疗后3周，治疗组、对照组总有效率分别为90．0％（27／30例）、73．3％（22／30例）。两组总有效率比较差异有统计学意义（P〉0．01）。结论腺苷钴胺联合阿昔洛韦治疗带状疱疹性神经痛安全、有效。Objective To observe the efficacy of eobamamide and acyclovir in the treatment of neuralgia in herpes zoster. Methods Sixty patients with neuralgia of herpes zoster were randomly divided into 2 groups, all of them were treated orally with acyelovir 0.2g, 5 times/d. Control group were added with cobamamide 0.5 mg, im,qd,and treatment group with Vit B12 0.5mg,im,qd. The treatement was lasted for 1 week and 3 weeks. Results The effective rates of treatment group and control group were 56.7%（17/13 cases） ,43.3%（13/30 cases） in 1 weeks and 90.0%（27/30 cases） ,73.3% （22/30 cases） in 3 weeks after the treatment respectively. There was statistical significant between the two groups（P〈0.01）. Conclusion The treatment of neuralgia in herpes zoster with cobamamide and acyclovir is a safe and effective method.

关 键 词：疱疹 带状 神经痛 腺苷钴胺类 阿昔洛韦 

分 类 号：R752.12[医药卫生—皮肤病学与性病学] R595.3[医药卫生—临床医学]