癫癎患者的短潜伏期体感诱发电位与临床相关性的研究  

The correlative study of short latency someatosensory evoked potentials and clinical in epileptics

作　　者：李增友[1] 许虹[2] 吕明华 王学峰[1] 全凤英[1] 

机构地区：[1]重庆医科大学附属第一医院神经内科,重庆400016 [2]昆明医学院附属第一医院神经内科 [3]云南省玉溪市第二人民医院神经内科

出　　处：《临床神经电生理学杂志》2009年第2期94-98,共5页Journal of Clinical Electroneurophysiology

摘　　要：目的：研究癫癎患者短潜伏期体感诱发电位（SLSEP）的变化规律及相互关系，并对SLSEP技术在其中的应用价值进行评价。方法：对癫癎患者在发作间期进行SLSEP检测，以潜伏期为观察指标，检测双侧N20、P40、P15、IN16、N16、N18、N19波潜伏期，并与正常人作对照。结果：癫癎组N20、P15、IN16、N16各波潜伏期较对照组明显延长（P〈0．01）；癫癎患者头颅CT／MRI异常组同侧记录的IN16潜伏期较头颅CT／MRI正常组的IN16波潜伏期延长（P=0．01）；癫癎患者脑电图异常组P15波潜伏期较脑电图正常组的延长（p=0．05）；病程5年以上组P40、P15波潜伏期较1-5年组延长（P=0．00、P=0．01），病程5年以上组P40波潜伏期较1年以下组延长（P=0．03）；用2种及以上抗癫癎药组IN16波潜伏期较未用抗癫癎药组的明显延长（P=0．01），用两种及以上抗癫癎药组IN16、N16、N18波潜伏期较用1种抗癫癎药组明显延长（p=0．01、P=0．02、P=0．02）；每月发作两次以上组P40波潜伏期较每月发作两次及以下组明显延长（P=0．04）。结论：癫癎患者存在脑功能障碍，并有相应的SLSEP改变。SLSEP检测技术可以评估癫癎患者的脑功能，并且能够动态观察比较，可对患者的疗效和预后评估提供指导。Objective：To investigate the correlations of short latency someatosensory evoked potentials（SLSEPs） and clinical in epileptics, and to assess the values of SLSEP techniques applied in this study. Methods： The epileptics in interictal were examined by SLSEP, and to investigate peak latencies of N20, P40 ,P15, IN16, N16. N18. N19. Results：As compared with SLSEPs of the control subjects, the patients＇ peak latencies of N20.P15,IN16,N16 significantly extended（P〈0.01）. In comparison between the epileptics with the abnormalities of cranial CT/MRI and the epileptics with the normalities of cranial CT/MRI,the former＇ peak latency of IN16 significantly extended（P=0.01）. In comparison between the epileptics with the abnormalities of electroencephalography and the epileptics with the normalities of electroencephalography,the former＇ peak latency of P15 significantly extended（P = 0. 05）. In compared between the courses of disease〉5 years and the courses of disease in 1-5 years, the former＇ peak latencies of P40.P15 significantly extended（P=0. 00,P=0. 01）;In comparison between the courses of disease〉5years and the courses of disease 〈 1 year, the former＇ peak latency of P40 significantly extended（P 0.03）. IN comparison between the epileptics took antiepileptic drugs（AEDs）≥2 and the epileptics took no AED, the former＇ peak latency of IN16 significantly（P=0.01） ;extended comparison between the epileptics took AEDs≥2 and the epileptics took AED= 1, the former＇ peak latencies of IN16,N16,N18 significantly extendison（ P=0.01, P= 0.02, P = 0.02 ）. In compared between the epileptics with the seizures〉2/month and the epileptics with the seizure≤2/month, the former＇ peak latency of P40 significantly extended（P=0.04）. Conelnsion： Epileptics have some brain dysfunctions . Thus, some components of SLSEP are abnormal. The eraluation of the brain functions in epileptics by using SLSEP. SLSEP is effective to direct the treatment and the prognosis of epileptics b

关 键 词：癫癎 短潜伏期体感诱发电位(SLSEP) 相关性 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]