酞丁安乳膏在大鼠局部皮肤上的毒理实验  

Study on the systemic safety in rats by topical skin application with Ftibamzone cream

作　　者：李新宇[1] 高纪伟[1] 徐兰芳[1] 唐美育[1] 沈珑瑛[2] 潘显道[2] 冷欣彦[3] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,江苏南京210042 [2]中国医学科学院北京协和医学院药物研究所北京协和药厂,北京100050 [3]南京农业大学动物医学院,江苏南京210014

出　　处：《华西药学杂志》2009年第2期168-170,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的研究酞丁安乳膏在大鼠体内的安全性,以了解酞丁安乳膏应用于局部皮肤后,对大鼠所产生的整体影响。方法给予大鼠局部皮肤酞丁安乳膏3个月,进行长期毒性试验。结果大鼠整体无明显异常。病理结果表明,酞丁安乳膏对各器官无明显毒性。结论酞丁安乳膏局部应用于大鼠皮肤较安全。OBJECTIVE To investigate the systemic effect on animals after topical application Ftibamzone cream. METHODS Long term toxicity test was conducted by topical application with Ftibamzone cream for three months on rat skin. RESULTS and CONCLUSION Abnormal responses in rats were not detected after topical application with Ftibamzone cream for three months and recovery period of 14 days. Data of pathological test indicated that there was no significnt toxicity to various organ in rats with Ftibamzone cream.

关 键 词：酞丁安 长期毒性试验 乳膏 皮肤 

分 类 号：R96[医药卫生—药理学]