毓麟合剂对自体移植复制子宫内膜异位症大鼠血清孕酮和雌二醇的影响  

Effect on Yu-Lin mixture on estradiol,progesterone of endometriotic rats

作　　者：李新液[1] 张玉萱[1] 徐玲玲[1] 年华[1] 

机构地区：[1]上海中医药大学岳阳中西医结合医院药剂科,上海200437

出　　处：《药学与临床研究》2009年第2期109-111,共3页Pharmaceutical and Clinical Research

摘　　要：目的:探讨毓麟合剂对自体移植复制子宫内膜异位症大鼠血清孕酮和雌二醇的影响。方法:取子宫内膜异位症(EMT)模型造模成功的大鼠30只,随机分为模型组、那曲酮组和毓麟合剂组各10只;另设假手术组10只,那曲酮组灌服2 mg.kg-1.d-1,毓麟合剂灌服11 g.kg-1.d-1,模型组对照组和假手术组灌服生理盐水,连续1个月;取血检测血清孕酮和雌二醇。结果:模型组大鼠血清孕酮和雌二醇水平升高,与假手术组相比具有显著性差异(P<0.01);那曲酮组和毓麟合剂组大鼠血清孕酮和雌二醇水平降低,与模型组相比有显著性差异(P<0.01)。结论:毓麟合剂可作用于EMT模型大鼠,使血清孕酮和雌二醇水平降低而治疗子宫内膜异位症。Objective：To study the effect and mechanism of Yu-Lin mixture in treatment of endometriosis. Methods：Rat endometriosis model was set up by self-endometria transplantation, serum estradiol （E2 ） ,progestrone （P） were detected after treatment with Yu-Lin mixture or control. Result：Serum E2 and P were depressed by activating Yu-Lin mixture. There was significant difference of each target between Yu-Lin mixture group and model group（P 〈 0.05 ）. Conclusion ：Yu-Lin mixture can inhibit the growth of endometrial transplants, which is related to the serum hormone, especially E2.

关 键 词：EMT 孕酮 雌二醇 毓麟合剂 不孕 

分 类 号：R965[医药卫生—药理学]