抗鸡致病性大肠杆菌中药的筛选及其疗效观察  

Screening and Efficacy Observation of Traditional Chinese Medicine Against Chicken Pathogenic Escherichia coli

作　　者：庞向红[1,2] 褚秀玲[3] 苏建青[3] 梁淑珍[2] 李全福[2] 胡满[1] 

机构地区：[1]河北农业大学动物科技学院,河北保定071001 [2]河北北方学院动物科技学院,河北张家口075131 [3]聊城大学农学院,山东聊城252059

出　　处：《安徽农业科学》2009年第9期4040-4041,4072,共3页Journal of Anhui Agricultural Sciences

基　　金：河北省教育厅资助项目(2007408)

摘　　要：[目的]为获得有效防治鸡大肠杆菌病的中药制剂奠定基础。[方法]以西药盐酸洛美沙星氯化钠注射液为对照,对15味中药及7个自拟中药复方进行药敏试验,并对7个中药复方和体外抑菌效果较好的单味中药进行体内试验。[结果]药敏试验结果表明,15味单味中药均有一定的抗大肠杆菌作用,其中以芦荟、石榴皮、地榆等抑菌效果明显。7个自拟复方中复方一、复方二和复方五的抗大肠杆菌效果较好。体内试验结果表明,中药对人工感染大肠杆菌的鸡只治疗效果优于西药,以复方一和复方二效果较好。[结论]中药制剂对鸡大肠杆菌病具有较好的治疗效果,但其在体内与体外的抑菌作用机制有所不同。[Objective] The aim of this study was to lay a foundation for obtaining effective traditional Chinese medicine preparations controlling chicken colibacillosis.[Method] With the western medicine Lomefloxacin Hydrochloride / Sodium Chloride Injection as the control,drug sensitivity tests of 15 traditional Chinese herbs and seven self-made Chinese herbal compounds were conducted.Subsequently,the single traditional Chinese herbs presenting good in vitro antibacterial effects against Escherichia coli and all the seven compounds were given to the chicken artificially infected with E. coli to observe their efficacies [Result] The results of drug sensitivity tests showed that all the 15 traditional Chinese herbs had certain antibacterial effects against E. coli, among which aloe, pomegranate find and radix sanguisorbae were the best. Compound 1, 2 and 5 had good antibacterial effects in vitro. By in vivo test, traditional Chinese medicines showed superior efficacy on chicken infected with E. coli than western medicine, and compound 1 and 2 performed good effects. [Conclusion] Traditional Chinese medicine preparation is good at controlling chicken colibacillosis, but their bacteriostasis mechanism in vivo is dif- ferent with that in vitro.

关 键 词：中药制剂 药敏试验 鸡大肠杆菌病 体内试验 

分 类 号：S853.72[农业科学—临床兽医学]