原位杂交检测与中药治疗肛周外阴HPV6/11型感染的对比研究  

Study of Treating the Perineum Infection of HPV 6/11 by Traditional Chinese Medicine

作　　者：王旭波[1] 张培影[1] 徐侠[1] 杨海燕[1] 王为[1] 

机构地区：[1]南京中医药大学附属医院徐州市中医院,江苏徐州221003

出　　处：《辽宁中医杂志》2009年第4期550-552,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：江苏省中医药局科研课题(HZ07099)

摘　　要：目的:探讨原位杂交技术检测肛周、外阴HPV(6/11型)感染的诊断价值,观察中医中药方剂治疗尖锐湿疣的疗效和价值。方法:采用原位杂交检测方法确诊和判定HPV感染,应用燥湿解毒、清热扶正方剂治疗尖锐湿疣患者,实验组82例,疣体切除加中药局部熏洗和口服汤剂,对照组81例行疣体切除。结果:实验组82例,HPV 6/11型均阳性,术后复发率7.32%(6/82),对照组81例HPV 6/11型均阳性,术后复发率20.98(17/81)%,差异有显著性(P<0.05)。结论:原位杂交技术检测肛周、外阴HPV感染客观、准确、可靠,清热扶正方剂治疗尖锐湿疣患者疗效显著、可降低尖锐湿疣的复发率。Objective：To explore the diagnostic value of detectiving perineum infection of Human papiuomavirus 6/11 type （ HPV 6/11 ） by in situ hybridization, and to sdudy the clinical effect and value of Clearing away Heat and Reinforcing Body Re- sistance Prescription in CA. Methods ：In situ hybridization was adapted to get a definite diagnosis of infection of HPV . The pa- tients with CA were treated by Clearing away Heat and Reinforcing Body Resistance Prescription. 163 cases with CA were includ- ed in this trail ,82 cases in trail group ,81 cases in control group. Patients in trail group received excision of warts ,local fumiga- tion,together with taking the prescription. While the control group only received the same operation therapy. Results：The detec- tions of HPV 6/11 in both group were all positive. The recurrence rate was 7.32% （6/82） ,20.98 （ 17/81 ） in two groups respec- tively. There was a significant difference between the two groups （P 〈 0.05 ）. Conclusion：In situ hybridization was objective, accu- rate and reliable to detect perineum infection of HPV. The effect of Clearing away Heat and Reinforcing Body Resistance Prescrip- tion was distingwished and it can decreased the recurrence rate of CA extremely.

关 键 词：人乳头瘤病毒 尖锐湿疣 中西医结合 原位杂交 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]