布洛芬颗粒溶出度测定方法研究  

The study of ibuprofen granules dissolution test method

作　　者：张芳[1] 

机构地区：[1]内蒙古医学院第一附属医院药剂部,010050

出　　处：《中国实用医药》2009年第10期14-15,共2页China Practical Medicine

摘　　要：目的建立布洛芬颗粒溶出度测定方法。方法采用紫外分光光度法测定。测定波长为:220 nm。溶出介质为pH7.2磷酸盐缓冲液。结果布洛芬溶液在3.0～15.0μg/ml范围内,吸收度与浓度呈良好的线性关系,r=0.999 3。样品精密度试验RSD为0.85%,样品供试液在12 h内稳定,样品加样回收率为99.9%,RSD为0.22%。结论该法操作简便,稳定可靠,专属性强,可以有效测定布洛芬颗粒溶出度,为控制布洛芬颗粒质量提供了依据。Objective To establish of ibuprofen particle dissolution method. Methods UV determination. Determination wavelength： 220 nm. pH 7.2 dissolution medium for PBS. Results Ibuprofen in 3.0 15.0 μg/ml solution, the degree of absorption and concentration was good linear relationship, r = 0. 999 3. Test samples precision RSD 0. 85% for the sample test solution within 12 h in the stability of the sample recovery rate was 99.9%, RSD was 0.22%. Conclusion This method is simple, stable and reliable, specific and effective determination of ibuprofen particle dissolution, in order to control particle dissolution of ibuprofen provides the basis for quality.

关 键 词：布洛芬 溶出度 测定方法 

分 类 号：R927[医药卫生—药学]