慢性乙型肝炎患者外周血IL-1β、mIL-2R、IL-10的检测及意义  

IL-1β,mIL-2R and IL-10 Levels in Peripheral Blood from Patients with Chronic Hepatitis B:Detection and Significance

作　　者：许文龙[1] 张国祥[1] 王红旗[1] 

机构地区：[1]浙江萧山医院临床医学检验中心,浙江萧山311201

出　　处：《中华医院感染学杂志》2009年第7期742-744,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨细胞因子IL-1β、mIL-2R、IL-10与慢性乙型肝炎患者血清五项标志物的相关性。方法应用化学发光免疫分析技术(CLIA)检测65例慢性乙型肝炎患者血清中IL-1β、mIL-2RI、L-10的水平;根据血清五项标志物检测结果,将65例慢性乙型肝炎患者分成两组,分别为HBeAg阳性组(33例,经检测HBV DNA全为阳性)、HBeAg阴性组(32例,经检测HBV DNA全为阴性),同时设正常对照组30例。结果慢性乙型肝炎患者中HBeAg阳性组、HBeAg阴性组IL-1β、IL-10浓度明显高于正常对照组,经统计学分析差异有统计学意义(P<0.05);HBeAg阳性组、HBeAg阴性组mIL-2R浓度明显低于正常对照组,经统计学分析差异有统计学意义(P<0.05)。结论在慢性乙型肝炎发病过程中,mIL-2R等细胞因子水平降低,IL-1βI、L-10等细胞因子水平升高,可导致机体免疫功能紊乱,同时与机体乙型肝炎病毒感染后的慢性化密切相关。OBJECTIVE To explore the relationship between cytokines（IL-1β, mIL-2R, IL-10） and hepatatis B virus（HBV） serum markers in patients with chronic hepatitis B（CHB）. METHODS The serum level of IL-1β, mIL-2R and IL-10 in 65 patients with CHB was measured with chemiluminescence immunoassay （CLIA）. RESULTS Of the patients with positive and negative HBeAg,the serum IL-1β and IL-10 levels were significantly higher than normal controls （P〈0.05）, but the serum mIL-2R level was significantly lower than normal controls （P〈0.05）. CONCLUSIONS In the course of CHB, the cytokines such as mIL-2R are decreased while IL-1β and IL-10 are increased, which might lead to chemiluminescence immunoassay immune function disorders and is closely associated with the persistence after HBV infection.

关 键 词：乙型肝炎 化学发光免疫分析技术 白细胞介素1Β 膜白细胞介素-2受体 白细胞介素-10 

分 类 号：R512.62[医药卫生—内科学]