注射用炎琥宁与头孢曲松钠的配伍稳定性试验  

Study on the Stability of Mixture of Potassium Sodium Dehydroandrographolide Succinate for Injection with Ceftriaxon Injection

作　　者：李海燕[1] 刘燕 梁燕芳[1] 邱小凌[1] 

机构地区：[1]广东省肇庆市第一人民医院,526021 [2]广东省肇庆医学专科学校,526021

出　　处：《中国医药指南》2009年第6期17-18,共2页Guide of China Medicine

摘　　要：目的考察炎琥宁与注射用头孢曲松钠在0.9%氯化钠注射液中的配伍稳定性。方法采用高效液相色谱法,以LunaC18(250mm×4.6mm,5μm);流动相,乙腈,0.02mol/L磷酸二氢钾,10%四丁基氢氧化铵(磷酸调pH5.0)(38∶60.5∶1.5);252nm为检测波长,测定注射用炎琥宁与注射用头孢曲松钠配伍后在室温下8h内的含量变化。结果配伍液中炎琥宁与头孢曲松钠含量无明显变化。结论注射用炎琥宁与注射用头孢曲松钠在0.9%氯化钠注射液可配伍使用。Objective To study the stability of the mixture of potassium sodium dehydroandrographolide succinate for injection with ceftriaxon injection in 0.9% sodium chloride injection. Method HPLC method was adopted in which consisted Luna C18column （250mm×4.6mm,5μm） was used. acetonitrile-0.02 mol/L potassium dehydrogenize phosphate-10% tetmbutylammonium hydrox- ide solution（pH 5.0）（38∶60.5∶1.5）as the mobile phase with detection wavelength at 252 nm.The contents were determined after mixing of potassium sodium dehydroandrographolide succinate with cefiriaxon injection in 0.9% sodium chloride injection under the room temperature within 8 hours. Result No significant differences were found in terms of the contents of the mixed solution. Conclusion The mixture of potassium sodium dehydroandrographolide succinate with ceflriaxon injection in 0.9% sodium chloride injection can be used at room temperature.

关 键 词：高效液相色谱法 炎琥宁 头孢曲松钠 配伍 稳定性 

分 类 号：R927.11[医药卫生—药学]