复方苦参注射液联合FOLFOX-4方案治疗晚期结直肠癌的临床研究  被引量:11

Compound Matrine Injection in Combination with FOLFOX-4 Regimen for Advanced Colorectal Cancer:A Clinical Study

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作  者:廖国清[1] 曲怡梅[1] 刘鹏辉[1] 王红梅[1] 解国清[1] 

机构地区:[1]解放军总医院第二附属医院肿瘤科,北京市100091

出  处:《中国医院用药评价与分析》2009年第3期207-208,共2页Evaluation and Analysis of Drug-use in Hospitals of China

摘  要:目的:观察复方苦参注射液在结直肠癌化疗中的作用。方法:应用苦参注射液配合FOLFOX-4方案化疗治疗结直肠癌125例(治疗组),与单纯化疗组125例对照。结果:同步组和序贯组的总有效率分别为61.6%和40.0%,差异有显著性(P<0.01);治疗组恶心、呕吐、肝功能损害发生率明显低于对照组(P<0.05),黏膜炎、腹泻轻于对照组,两组比较有明显差异。治疗组白细胞降低的程度低于对照组(P<0.05),治疗组治疗后的免疫功能测定指标有显著增加(P<0.01)。结论:恶性肿瘤化疗时联合使用复方苦参注射液,可明显减轻化疗的不良反应,提高患者的免疫功能。OBJECTIVE: To evaluate the efficacy of Compound Radix Sophorae Flavescentis Injection combined with chemotherapeutic drug for colorectal cancer. METHODS: 125 patients with colorectal cancer (trial group) were assigned to receive Compound Radix Matrine Injection combined with FOLFOX - 4 chemotherapy, and another 125 cases (control group) received chemotherapy alone. RESULTS: There were significant differences between the trial group and the control group in total effective rates (61.6 % vs. 40.0% ) (P 〈 0.01 ). The incidences of nausea, vomiting and hepatic lesion were significantly lower in the trial group than in the control group ( P 〈 0.05) and the mucositis and diarrhea in the trial group were less severe than in the control group, showing significant difference between the two groups. The reduction degree of the white blood cells in the trial group was lower than in the control group ( P 〈 0.05), and the immune function indexes in the trial group after treatment enhanced significantly ( P 〈 0.01 ). CONCLUSION : The addition of Compound Radix Sophorae Flavescentis Injection to chemotherapeutic drug can significantly attenuate the toxic side effects of chemotherapy while enhancing patients' immune function.

关 键 词:复方苦参注射液 FOLFOX-4 结直肠癌 

分 类 号:R979.1[医药卫生—药品]

 

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