灯盏细辛注射液对急性脑梗死患者白细胞介素13及神经功能缺损程度的影响  

Influences of Dengzhanxixin Injection on Level IL13 and Degree of Neurological Deficit in Patients with Acute Cerebral Infarction

作　　者：吴育彬[1] 吴映华[1] 奚宝珊[1] 

机构地区：[1]广东省汕头市汕头大学医学院第一附属医院神经内科

出　　处：《中国卒中杂志》2009年第3期218-221,共4页Chinese Journal of Stroke

基　　金：广东汕头市重点科技计划资助项目[2006(20)]

摘　　要：目的观察灯盏细辛注射液对急性中度脑梗死患者白细胞介素13（IL-13）及神经功能缺损程度的影响。方法选择急性中度脑梗死患者102例，随机分灯盏细辛注射液治疗组62例和对照组40例，两组基础治疗相同，对照组用丹参注射液16ml，治疗组用灯盏细辛注射液40ml／d，均以14d为1个疗程，共用2个疗程。比较两组IL-13水平、神经功能缺损程度评分的变化。同期检测30例体检健康者血清IL-13水平。结果健康者血清IL-13水平（28．7±3．2）ng／L；两组患者血清IL-13水平第7d时表达最高；第7、14d，治疗组血清IL-13水平低于对照组[（48．3±5．3）ng／L vs（51．1±3．2）ng／L，P〈0．05；（39．8±4．5）ng／L vs（43．7±3．5）ng／L，P〈0．01]；第14、28d治疗组神经功能缺损程度明显较对照组减轻[（14．9±3．6）分vs（21．4±4．0）分，P〈0．01；（12．7±2．7）分vg（15．8±4．1）分，P〈0．05]。结论灯盏细辛注射液可通过抑制急性脑梗死患者的炎症反应，改善患者的预后。Objective To observe the influences of Dengzhan Xixin injection on both interleukin-13 level and moderate neurological deficit extent in patients with cerebral infarction. Methods 62 cases（treatment group） and 40 cases（control group） with moderate cerebral infarction were treated with the same basic therapy. Control group treated with Dangsheng injection, treatment group injected with Dengzhanxixin injection for 4 weeks. The changes in serum levels of IL-13 and neurological deficit were compared. Normal IL-13 level was calculated by 30 healthies. Results Normal IL-13 level was 28.7±3.2 ng/L. The 7^th day＇s IL-13 was the highest level on patients. The level IL-13 in treatment group was obviously lower than that in control group on the 7^th and 14^th day. The neurological deficit extent in treatment group was more obviously alleviated than that did in control group on 2^nd and 4^th week. Conclusion Dengzhanxixin injection was able to improve the prognosis of patients with moderate cerebral infarction by means of inhibiting inflammatory.

关 键 词：脑梗死 灯盏细辛注射液 白细胞介素13 

分 类 号：R277.7[医药卫生—中医学]