咖啡酸苯乙酯的合成研究进展  

Research progress in synthesis of caffeic acid phenyethyl ester

作　　者：卢定强[1,2] 蒋奔[1] 王俊[1] 赵辉[1] 凌岫泉[1] 刘骥[1] 

机构地区：[1]南京工业大学制药与生命科学学院,江苏南京210009 [2]江苏省药物研究所,江苏南京210009

出　　处：《现代化工》2009年第4期20-24,共5页Modern Chemical Industry

基　　金：国家自然科学基金资助项目(20876076)

摘　　要：咖啡酸苯乙酯是近年来新药研发的热点化合物,其抗肿瘤活性备受关注。介绍了不同底物合成咖啡酸苯乙酯的工艺路线及其催化机理,其中重点分析了绿原酸水解酶和脂肪酶对定向合成咖啡酸苯乙酯的生物催化特性和反应特征,并展望了咖啡酸苯乙酯合成方法的发展趋势及应用前景。Caffeic acid phenethyl ester with anti-cancer activity has attracted considerable attention. Synthetic routes and its catalytic mechanisms of caffeic acid phenethyl ester from different substrates are reviewed. The bio-synthetic characteristics by chlorogenate hydrolase and hpase are mainly discussed, respectively. The development trends and prospects of synthetic methods related with caffeic acid phenethyl ester are looked forward to.

关 键 词：咖啡酸苯乙酯 提取 合成 生物催化 抗病毒活性 

分 类 号：TQ463[化学工程—制药化工]