秀丽线虫脂肪积累调控的生理与分子机制  

Physiological and Molecular Control of Lipid Accumulation in Caenorhabditis Elegans

作　　者：许雪梅[1] 王大勇[1] 

机构地区：[1]东南大学医学院遗传与发育学系发育与疾病相关基因教育部重点实验室,南京210009

出　　处：《生理科学进展》2009年第2期129-134,共6页Progress in Physiological Sciences

基　　金：国家自然科学基金(30771113);教育部新世纪优秀人才项目基金资助课题

摘　　要：脂肪积累是一个复杂的生理过程,模式动物秀丽线虫(以下简称线虫)已经成为目前研究脂肪积累的重要模型。线虫中的脂肪酸代谢通路与其他物种中的代谢是基本一致的,很多关键的代谢调节基因的功能已经得到鉴定。线虫中脂肪积累涉及至少4个核心调控通路,分别为胰岛素和转化生长因子β(TGF-β)信号通路、sbp-1/mdt-15介导的信号通路、核激素受体nhr-49介导的信号通路与雷帕霉素靶标(TOR)和氨基己糖介导的信号通路。此外,神经递质5-羟色胺、多巴胺和谷氨酸参与了脂肪积累的调控,而tub-1和bbs-1可以介导对脂肪积累的神经调控,暗示了纤毛结构与感觉神经元在脂肪积累中可能的重要功能。线虫中的研究工作对人类肥胖症等代谢疾病的研究具有重要的提示作用。Fat storage is a complex physiological process, and model organism of Caenorhabditis elegans has already been explored as an important model to study lipid accumulation. The lipid particles or fatty acid can be stained or labeled with Sudan Black B or Neil Red. The metabolism pathways for fatty acid synthesis and breakdown in nematodes are almost identical to those in other organisms, and functions of many genes encoding the key regulation enzymes have been identified. At least four central regulation pathways are involved in the fat storage control in nematodes： insulin and TGF-β signaling pathway, sbp- 1/mdt-15 mediated pathway, nhr-49 mediated pathway, and TOR and hexosamine pathway. Moreover, neurotransmitters 5-HT, dopamine, and glutamate were found to participate in the control of lipid accumulation. In addition, involvement of tub-1 and bbs-1 in neuronal control of fat storage suggest the possibly important roles of amphid structure and sensory neurons in regulating lipid accumulation. The data obtained in C. elegans on fat storage control will contribute largely to the study on metabolism related diseases, such as obesity, in human beings.

关 键 词：秀丽线虫 脂肪积累 生理调控 分子机制 

分 类 号：R723.14[医药卫生—儿科]