降压调脂胶囊对糖尿病早期肾损害模型大鼠NOS和ET-1表达的影响  

Effect of adjusting blood pressure and blood fat capsule on ET-1 and NOS in early-stage diabetic nephropathy rats

作　　者：赵云芳[1] 李晓冰[2] 李瑞琴[1] 闫利利[1] 张立 

机构地区：[1]河南中医学院,河南郑州450008 [2]上海中医药大学,上海201203 [3]南阳市第一人民医院,河南南阳474000

出　　处：《中成药》2009年第4期523-526,共4页Chinese Traditional Patent Medicine

摘　　要：目的:探讨降压调脂胶囊(当归、泽泻、茯苓、白术、川芎、白芍、槟榔、陈皮、紫苏叶)对由链脲佐菌素诱发的糖尿病模型大鼠肾脏病变的保护机制。方法:采用健康雄性Wistar大鼠70只,随机分为正常组、糖尿病组、降压调脂胶囊治疗组和缬沙坦阳性对照组。连续用药4周后,收集大鼠的尿、血、肾组织标本,进行生物化学和免疫组化检测。结果:大鼠尿微量白蛋白、β2-微球蛋白、内生肌酐清除率各组间均有统计学意义;肾组织内皮素-1(ET-1)和一氧化氮合酶(NOS)表达均有统计学意义(P<0.01)。结论:降压调脂胶囊防治DN的作用与其抑制肾脏ET-1、NOS表达等因素有关。AIM： To investigate the protecting mechanisms of adjusting blood pressure and blood fat capsule （Radix angelicae sinesis, Rhizoma alismatis, poria, Rhizoma attactylodis macrocephalae, Rhizoma Chuanxiong, Radix Paeoniae alba, semen arecae, Folium perillae） in diabetic nephropathy rats induced by streptozotocin. METHODS： Forty-eight health male Wister rats were randomly divided into normal group, diabetic nephropathy group ,adjusting blood pressure and blood fat capsule group and valstatan group . After experiment urine, blood, kidney samples were taken, and immunohistochemistry were performed. RESULTS： 24 hour urinary microalbumin, creatinine clearance, β2-microglobulin, creatinine clearance ET-1 and NOS in kidneys had distinct difference among three gruops. CONCLUSION： The provention and cure of DN function of adjusting blood pressure and blood fat capsule bears relationship with inhibition of ET-1, NOS＇s expression.

关 键 词：降压调脂胶囊 糖尿病早期肾损害 模型大鼠 

分 类 号：R285.6[医药卫生—中药学]