子宫内膜异位症患者血清EMAb、VEGF、IL-2及IL-2R水平变化  

Clinical Significance of Determination of Changes of Serum EMAb,IL-2,IL-2R and VEGF Levels in Patients with Endometriosis

作　　者：闵捷燕[1] 

机构地区：[1]扬州大学第五临床医学院常熟二院妇产科,215500

出　　处：《放射免疫学杂志》2009年第2期107-110,共4页Journal of Radioimmanology

摘　　要：目的:探讨子宫内膜异位症患者血清EMAb、VEGF、IL-2及IL-2R水平的变化及与病情进展的关系。方法:患者血清EMAb采用酶联免疫分析;VEGF、IL-2及IL-2R测定均采用放射免疫分析。结果:45例子宫内膜异位症患者的四项指标测定结果显示,EMAb阳性检出率治疗前组极显著高于对照组(P<0.01);经中西医结合治疗3个月后EMAb阳性检出率显著降低,但与对照组比较阳性检出率仍显著高于对照组(P<0.05)。VEGF水平治疗前组也极显著高于对照组(P<0.01);中西医结合治疗3个月后水平显著下降,与对照组比较已无显著差异(P>0.05)。IL-2水平则在治疗前组水平极显著降低(P<0.01);中西医结合治疗3个月后含量明显上升,与对照组比较无显著性差异(P>0.05)。IL-2R治疗前升高极显著(P<0.01);3个月中西医结合治疗后血清水平明显下降,测定结果与对照组比较已无显著差异(P>0.05)。结论:子宫内膜异位症患者血清EMAb、VEGF、IL-2及IL-2R四项指标发生了显著变化,其测定有助于该病的辅助诊断、病情评估及预后判断。Objective To investigate the relationship between the progress of the disease process and changes of serum antiendometrium antibody（EMAb）, interleukin -2（IL-2）, interleukin-2 receptor （IL-2R） and vascular endothelial growth factor（VEGF） levels in patients with endometriesis. Methods Serum EMAb （with ELISA） and VEGF, IL -2, IL -2R （with RIA） levels were measured in 45 patients with endometriosis both before and after treatment as well as in 35 controls. Results Before treatment with integrated traditional and western medicine, the positive rate of serum EMAb were significantly higher in patients with endometriosis than that in the controls （P 〈 0.01 ）,The serum VEGF, IL -2R levels were also significantly higher in the patients and the serum IL -2 levels were significantly lower in the patients than those in the controls （P all 〈 0.01 ）. After treatment for three months, the positive rate of EMAb dropped markedly but remained significantly higher than that in controls （ P 〈 0.05）. Serum levels of all other three parameters were corrected and were not significantly different from those in controls （P 〉 0. 05）. Conclusion Determination of changes of serum EMAb, IL - 2, IL - 2R and VEGF levels in patients with endometriosis were helpful for assessment of the progress of disease process and outcome prediction.

关 键 词：子宫内膜异位症 抗子宫内膜抗体 血管内皮生长因子 白细胞介素-2 白细胞介素2受体 

分 类 号：R542.22[医药卫生—心血管疾病] R711.71[医药卫生—内科学]