不透X线标志物检测胃排空对糖尿病胃轻瘫诊断试验的评价  

Radiopaque markers of gastric emptying for diagnosis of diabetic gastroparesis

作　　者：李明贤[1] 贾林[2] 全红[1] 黄耀星[2] 邹德怀[3] 朱旭[3] 徐宏刚[4] 

机构地区：[1]汕头大学医学院附属粤北人民医院消化内科,广东省韶关市512026 [2]广州医学院附属广州市第一人民医院消化内科 [3]广州医学院附属广州市第一人民医院核医学科 [4]广州医学院附属广州市第一人民医院放射科

出　　处：《中国医药》2009年第4期267-268,共2页China Medicine

摘　　要：目的评价不透X线标志物（ROMs）检测胃排空对糖尿病胃轻瘫的诊断效能及应用价值。方法对50例2型糖尿病患者采用ROMs法与核素显像法进行胃排空测定。分别记录6h胃排空率（GER）和胃半排空时间（GEt1/2），分析ROMs法诊断的敏感性与特异度。结果ROMs法6h胃排空率为100％时，敏感度、特异度分别为88．9％和81．3％；6h胃排空率为90％时，敏感度、特异度分别为72．2％和93．8％。受试者工作特性曲线下面积为0．884，Kappa值为0．67，糖尿病胃轻瘫发生率44％（22／50）。结论ROMs和核素显像检测胃排空具有良好的相关性，与金标准（核素显像）比较，ROMs法具有较高的特异度、准确度和Kappa值，一致性和信度好，且较简便，检测费用较低，适合糖尿病胃轻瘫的人群流行病学调查或社区发病学调查。Objective To evaluate Radiopaque markers of gastric emptying for diagnosis of diabetic gastroparesis. Methods Fifty patients with type 2 diabetes mellitus were enrolled. The gastric empty were measured by radionuclide imaging （RNI）, radiopaque markers （ROMs）, 6 hour gastric evacuation rate （GER） and GE1/2. Results The sensitivity and specificity were 88.9% and 81.3% respectively when 6 hour GER was 100%, and they were 72.2% and 93.8% respectively when 6 hour GER was 90%. The area under ROC curve and the Kappa value were 0.884, 0.67, respectively. The prevalence of DGP was 44%. Conclusion There is close correlation between RNI and ROMs for measuring gastric emptying. ROMs is good for evaluating morbidity or epidemiology of DGP.

关 键 词：糖尿病胃轻瘫 不透X线标志物 核素显像 

分 类 号：R587.2[医药卫生—内分泌]