牛黄解毒片中不同单味组分对雄黄可溶性砷含量影响的比较研究  

Influence of the different components in Niuhuang Jiedu Tablets on solubility of arsenic in realgar

作　　者：徐智[1,2] 俞珊珊[2] 黄可龙[2] 

机构地区：[1]中南大学湘雅医院药剂科,湖南长沙410008 [2]中南大学化学化工学院,湖南长沙410083

出　　处：《中国生化药物杂志》2009年第2期121-123,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：中南大学研究生学位论文创新选题立项资助项目(编号:2340-77234)

摘　　要：目的研究牛黄解毒片中各单味组分对雄黄可溶性砷含量的影响。方法采用雄黄与牛黄解毒片中的7种单味药按牛黄解毒片处方比例分别组方分为9组供试品并经人工胃液处理后,用分光光度法分别测定可溶性砷的含量。结果与雄黄组相比,雄黄与处方中各组分单独组方后测得的可溶性砷含量均有不同程度降低。其中大黄+雄黄组和甘草+雄黄组使可溶性砷含量减少为84.9%和81.1%,而冰片+雄黄组等影响不显著。结论牛黄解毒片中的大黄、甘草等与雄黄配伍能较显著地抑制雄黄中可溶性砷的溶出,为进一步探讨雄黄复方中影响可溶性砷盐的主要物质提供参考依据。Purpose To study the effects of the different components in Niuhuang Jiedu Tablets on solubility of arsenic in realgar. Methods The samples tested were divided into 9 groups by using realgar and the 7 different components in Niuhuang Jiedu Tablets. According to the original formula of Niuhuang Jiedu Tablets they were pretreated with simulated gastric juice respectively, and then concentrations of soluble arsenic were determined by UV spectrophotometry. Results Contents of soluable arsenic in simulated gastric juice--pretreated realgar with components in Niuhuang Jiedu Tablets or the compomd formula were decreased in different de- gree than those in simulated gastric juiee--pretreated realgar. Rhubarb ＋ realgar group and glycyrrhiza ＋ realgar group were decreased significantly and the content of soluble arsenic is 84.9% and 81.1%, lower than that in realgar. However, borneol ＋ realgar group had no significant influence. Conclusion Rhubarb and glycyrrhiza probably has inhibitory effect on solubility of arsenic in realgar. The paper can provide reference for the further study on the main material of the effects on solubility of arsenic in realgar.

关 键 词：牛黄解毒片 雄黄 单味组分 可溶性砷含量 

分 类 号：R927.1[医药卫生—药学]