右旋布洛芬缓释胶囊的释放度考察  

The Delivery Test of Modified Release Capsule of Dex-ibuprofen

作　　者：杨成雄[1] 赵平华 

机构地区：[1]荆楚理工学院化工与药学院,湖北荆门448000 [2]荆门市药品检验所,湖北荆门448000

出　　处：《荆门职业技术学院学报》2009年第2期39-42,共4页Journal of Jingmen Technical College

摘　　要：目的:考察右旋布洛芬缓释胶囊的释放度。方法:采用转篮法,溶出介质为pH6.0的磷酸盐缓冲液,对研制的右旋布洛芬缓释胶囊的三批样品的释放均一性和辅料、胶囊以及滤膜对释药的影响进行考察。结果:三批样品的各时段取样点的释放度相差不大,均匀度较好,均在规定的范围内;辅料、胶囊和滤膜对释药试验的结果没有干扰。结论:研制右旋布洛芬缓释胶囊释药稳定,其释放度测定法可以作为其质量控制的方法。Objective：The delivery test of modified release capsule of Dex -ibuprofen. Methods：The delivery test of modified release capsule of Dex - ibuprofen had been done in buffer phosphate（pH6.0） by rolling basket,and investigate the effect by adjuvant, capsule and filter membrane to modified release capsule of Dex - ibuprofen. Results：The delivery test of modified release capsule of Dex - ibuprofen had no difference in three group samples and was not been able to change by adjuvant,capsule and filter membrane. Conclusion：The delivery test of modified release capsule of Dex - ibuprofen was stable and good and can control its quality.

关 键 词：盐酸曲马多 口腔崩解片 溶出度 均匀度 质量控制 

分 类 号：TP751.1[自动化与计算机技术—检测技术与自动化装置]