特发性血小板减少性紫癜复发与病毒感染关系的研究  

Study on the correlation between virus infection and the recrudesce of idiopathic thrombocytopenic purpura

作　　者：孙东明[1] 魏金铠[1] 杨小巍[1] 许月红[1] 石瑄[1] 

机构地区：[1]河北大学附属医院儿科,河北保定071000

出　　处：《医学研究与教育》2009年第1期29-29,32,共2页Medical Research and Education

基　　金：河北省科学技术研究与发展计划项目(编号:052761714)

摘　　要：目的探讨儿童ITP复发与病毒感染的关系。方法用酶联免疫法检测65例复发ITP患儿并40例对照组血清巨细胞病毒(CMV)、EB病毒(EBV)、腺病毒(ADV)、单疱病毒(HSV)特异性IgM抗体。结果65例复发ITP患儿感染阳性率为61.5%,较对照组有显著性差异。结论病毒感染是ITP患儿复发的重要因素之一。Objective To explore the correlation between virus infection and the recrudesce of idiopathic thrombocytopenic purpura.Methods 65 patients with ITP（aged 1 to 13 years old,35 male and 30 female）and 40 normal children for the control group（aged 1-13 years old,24 male and 16 female）were enrolled.Indirect ELISA was developed to detect the antibodies IgM and cytomegalo virus（CMV）,EB virus,adeno virus（ADV） and human herpes virus（HHV）in sera of 2 groups.Results The total positive rate of virus related antibodies in ITP children are higher than that in the control group.There was a significant difference（P〈0.01）.Conclusion Virus infection could be one of the important causes which lead to the repeated onset of ITP.

关 键 词：特发性血小板减少性紫癜 酶联免疫吸附法 病毒感染 

分 类 号：R558.2[医药卫生—血液循环系统疾病]