免疫抑制剂的中药干预减毒增效研究与意义  

Significance and Reseach of Attenuation and Synergia for the Traditional Chinese Medicine Using in Immunosuppressant

作　　者：崔雪娜[1] 王四旺[1] 

机构地区：[1]第四军医大学药学系药物研究所,陕西西安710032

出　　处：《亚太传统医药》2009年第4期112-115,共4页Asia-Pacific Traditional Medicine

摘　　要：目的:针对免疫抑制剂在临床应用中存在明显毒副作用的现状,探索和构建免疫抑制剂中药干预减毒增效的新策略。方法:检索近30年国内外大量文献,采用分析、对比、提炼等方法进行综述。结果:①免疫抑制剂是治疗移植排斥反应和自身免疫性疾病必不可少的有效治疗药物,但长期临床应用可导致机体免疫功能低下、感染、诱发肿瘤等明显毒副作用,至今尚无有效防治措施;②免疫抑制剂的中药干预减毒增效未开展深入研究。结论:免疫抑制剂的中药干预减毒增效策略对于临床免疫性疾病的高效低毒治疗具有重要意义。Objective.. To explore and construct the new strategy of attenuation and synergia for the Traditional Chinese Medicine （TCM） using in immunosuppressant, in connection with the status of the obvious side effects of immunosuppressant for clinical application. Methods： The author summarizes large amounts of domestic and foreign literature through nearly 30 years using analysis, comparison and refining. Results： 1. The immunosuppressant is indispensable in transplantation rejection and autoimmune diseases, but it can lead to hypofunction of immune system, infection, tumor-induced, and there is no fundamental treatment methods for this. 2. We have no in-depth study of attenuation and synergia for the TCM using in irnmunosuppressant. Conclusions： Study of attenuation and synergia for the TCM using in immunosuppressant is of great significance for clinical treatment of immune disease high in effectiveness and low in toxicity, worth in-depth development.

关 键 词：免疫抑制剂 中药 减毒 增效 

分 类 号：R979.1[医药卫生—药品]