针刺结合益智健脑颗粒治疗阿尔茨海默病疗效观察  

Clinical observation on acupuncture combined with Yizhi Jiannao Granules for treatment of Alzheimer' s disease

作　　者：彭贤文[1] 董克礼[1] 

机构地区：[1]中南大学湘雅三医院中医科,湖南长沙410013

出　　处：《中国针灸》2009年第4期269-271,共3页Chinese Acupuncture & Moxibustion

基　　金：湖南省自然科学基金资助项目:07JJ5017

摘　　要：目的:观察针刺结合益智健脑颗粒对阿尔茨海默病的临床疗效及对患者智能状况、日常生活和社会活动能力的影响。方法:将84例患者随机分3组,各28例。针药组采用针刺百会、四神聪、大椎、关元等穴结合益智健脑颗粒治疗;中药组单用益智健脑颗粒治疗;西药组口服盐酸多奈哌齐(安理中)治疗。评价和比较各组治疗12周前后及组间简易精神量表(MMSE)、日常生活能力表(ADL)等神经量表评分以及临床疗效。结果:针药组、中药组及西药组治疗后MMSE、ADL评分均较前有改善,但针药组的效果更好,差异有统计学意义(P<0.05)。针药组总有效率为85.7%,优于中药组的71.4%和西药组的67.9%。结论:针刺结合益智健脑颗粒治疗阿尔茨海默病能显著改善患者智能状况,提高日常生活和社会活动能力,疗效优于单用益智健脑颗粒和西药安理申治疗。Objective To observe clinical therapeutic effect of acupuncture combined with Yizhi Jiannao Granules for treatment of Alzheimer＇ s disease and its effects on intelligence, daily life and social activity ability. Methods Eighty-four cases were randomly divided into 3 groups, 28 cases in each group. The combined acupuncture and medi-cation group was treated with acupuncture at Baihui （GV 20）, Sishencong （EX-HN 1）, Dazhui （GV 14）, Guanyuan （CV 4）, etc. and oral administration of Yizhi Jiannao Granules; the Chinese herb group was treated with Yizhi Jiannao Granules, and the western medicine group with oral administration of Aricept. The scores for the Mini-Mental State Examination （MMSE）, Ability of Daily Life （ADL） and the therapeutic effects were assessed and compared before treatment and after treatment for 12 weeks among the groups. Results After treatment, the scores for MMSE and ADL were improved in the combined acupuncture and medication group, the Chinese herb group and the western medicine group, which were better in the combined acupuncture and medication group （P〈0. 05）. The total effective rate of 85.7% in the combined acupuncture and medication group was better than 71.4% in the Chinese herb group and 67.9% in the western medicine group. Conclusion Acupuncture combined with Yizhi Jiannao Granules has a significant therapeutic effect on Alzheimer＇s disease, which is better than that of Yizhi Jiannao Granules or Aricept.

关 键 词：针药并用 阿尔茨海默病 益智健脑颗粒 

分 类 号：R246.6[医药卫生—针灸推拿学]