胸髓横断大鼠减重平板步行训练后腰髓前角神经元超微结构的可塑性变化  

The ultrastructural plasticity character in anterior horn neurons of lumbar cord in rats after transthoracic spinal cord injury by BWSTT

作　　者：张缨[1] 纪树荣[1] 孙异临[2] 范晓华[3] 周红俊[1] 刘根林[1] 郑樱[1] 郝春霞[1] 王一吉[1] 

机构地区：[1]中国康复研究中心北京博爱医院、首都医科大学康复医学院,北京100008 [2]天坛医院电镜中心 [3]山东省立医院

出　　处：《中国康复医学杂志》2009年第4期306-308,I0002,共4页Chinese Journal of Rehabilitation Medicine

摘　　要：目的:探索步行训练提高脊髓损伤(SCI)后运动功能的脊髓可塑性机制。方法:84只成年雌性Wistar大鼠随机分为假手术组(n=18)、胸髓横断模型组(n=33)、SCI后减重平板步行训练(BWSTT)治疗组(n=33),分别于术后第7天、15天、45天,通过光镜和电镜观察SCI大鼠脊髓腰膨大内前角神经元形态结构的变化。结果:胸髓横断大鼠BWSTT后,腰髓前角神经元超微结构出现代偿性改变。结论:BWSTT后胸髓横断大鼠可通过增强脊髓损伤平面以下腰髓前角神经元的可塑性,促进其后肢运动功能的恢复。Objective：To investigate the spinal cord plasticity mechanism of locomotor training on improving locomotion after transthoracie spinal cord injury （SCI）. Method：Eight-four adult female rats were divided into Sham, SCI and post SCI body-weight-support treadmill training （BWSTT） groups. The morphology of intact lumbar enlargement （caudal to the lesion） was observed under light microscope and electron microscope at the 7^th d, 15^th d and 45^th d postoperatively. Result： After BWSTT uttrastructure of neurons in lumbar cord anterior horn of transthoraeie SCI rats appeared compensative changes. Conclusion：BWSTT can improve locomotion of transthoracic SCI rats by promoting the neuronal plasticity of lumbar cord anterior horn.

关 键 词：脊髓损伤 减重平板步行训练 超微结构 脊髓可塑性 

分 类 号：R493[医药卫生—康复医学] R651.2[医药卫生—临床医学]