同型半胱氨酸对内皮细胞凋亡及JNK表达的影响  

The Effects of Homocysteine on JNK Express and Apoptosis of Human Umbilical Veins Endothelial Cell.

作　　者：何志勇[1] 叶小军[2] 邵胜敏[1] 

机构地区：[1]温州医学院附属第二医院神经内科,浙江温州325003 [2]杭州市第二人民医院,浙江杭州310015

出　　处：《心脑血管病防治》2009年第2期100-102,共3页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

基　　金：温州市科技局资助(Y2005A143)

摘　　要：目的了解同型半胱氨酸(Homocysteine,Hcy)对内皮细胞凋亡及JNK表达的影响。方法用不同浓度的Hcy处理内皮细胞后,TUNEL方法检测细胞凋亡,Western Blot检测细胞磷酸化JNK的表达。结果随着Hcy浓度的升高,细胞凋亡数目明显增加,各组细胞磷酸化JNK的表达也逐步增强,且具有显著性正相关。结论Hcy能引起内皮细胞凋亡及磷酸化JNK表达的增强。Objective To investigate the effects of homocysteine （Hcy） on endothelial cell apoptosis and the expression of JNK. Methods After treated with different concentrations of Hcy, the apoptosis was detected by TUNEL and JNK expression was examined with Westem Blot assay. Results Hcy promotes both endothelial cells apoptosis and the expression of phospho-JNK in a dose-dependent manner. Conclusions Hey can induce endothelial cell apoptosis and promote phospho-JNK expression.

关 键 词：同型半胱氨酸 内皮细胞 JNK 脐静脉 

分 类 号：R543[医药卫生—心血管疾病]