参丹饮对不稳定型心绞痛患者血栓调节蛋白和内皮素-1的影响  

Effect of ShenDanYin on Function of Thrombomodulin and Endothelin-1 in Patients with Unstable Angina Pectoris

作　　者：毛以林[1] 简维雄[2] 袁肇凯[2] 刘叶辉[1] 孙贵香[2] 

机构地区：[1]湖南中医药大学第二附属医院心血管内科,湖南长沙410005 [2]湖南中医药大学中医诊断研究所,湖南长沙410005

出　　处：《中华中医药学刊》2009年第2期267-269,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30271574);湖南省教育厅科研项目(04C442)

摘　　要：目的:探讨参丹饮治疗不稳定心绞痛(UA)时对血管内皮功能的影响。方法:90例UA患者随机分成中医组、西医组、中西医结合组各30例,治疗组予中药参丹饮,西药组予常规西药治疗,中西结合组前两组治疗均给予。分别比较3组心绞痛分级、中医证候积分,测定治疗前后血栓调节蛋白(TM)、内皮素(ET-1)水平。结果:用药后3组UA患者心绞痛均明显改善,组间比较无显著性差异(P>0.05)。中医证候积分、TM、ET-1水平用药后各组均有显著降低(P<0.05)。在降低TM、ET-1方面,中医组、西医组与中西医结合组比较均具有显著性差异(P<0.05)。结论:参丹饮能通过降低血浆TM、ET-1水平,保护不稳定型心绞痛患者的血管内皮功能。Objective：To evaluation the Effect of ShenDanYin（SDY）on Function of Thrombomodulin（TM） and Endothelin-1（ET-1） in Patients with Unstable Angina Pectoris（UAP）.Methods：90 UAP patients were randomly divided into TCM group,the western medicine（WM）group and the combined TCM and WM（TCM-WM） group.Every group have 30 patients.,the TCM group was given Chinese drug SDY,the WM group was treated by western medicine,to the TCM-WM group,all the treatment usesd in both TCM and WM group was given.Angina degree,calculus of TCM syndrome,the levels of TM and ET-1 were evaluated in every group befor and after treatment was given.Results：Angina degree were improved in all groups（P〈0.05）,but insignificant difference wasn＇t found between three groups.calculus of TCM syndrome,The level of TM and ET-1 markedly decreased in all groups after treatment was given（P〈0.05）.The level of TM and ET-1 in the TCM group and WM group was lower than that in the TCM-WM group with insignificant difference（P〈0.05）.Conclusion：SDY might protect the vascular endothelium by decreasing blood levels of TM and ET-1 in Patients with Unstable Angina Pectoris.

关 键 词：不稳定型心绞痛 血栓调节蛋白 内皮素-1 参丹饮 

分 类 号：R259.414[医药卫生—中西医结合]