活血利水方治疗腰椎间盘突出症处方的筛选优化  

Formulation Optimization of Lumbar Intervertebral Discprolapse Treated by the Decoction of Stimulating Blood Circulation to End Stasis and Diuresis

作　　者：邰东旭[1] 房凌桥[1] 房景奎[1] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032

出　　处：《中华中医药学刊》2009年第2期380-383,共4页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:基于实验筛选、优化运用活血利水法治疗腰椎间盘突出症的中药小复方,得出最佳处方配伍和最佳剂量配比,为临床治疗提供科学的实验依据。方法:运用拆方研究方法,以比较特异的药效学指标为评价指标,以均匀设计法进行处方最佳配伍和最佳剂量配比的比较研究。结果:经初筛得出中药小复方,并以均匀设计法得出了处方最佳配伍及最佳剂量配比是:药物1:40g,药物2:30g,药物3:20g,药物4:0g,药物5:35g。结论:应用方剂数据库、均匀设计、结合专业知识和具体实验结果进行处方筛选优化方法可行。Objective：Based on the experimental optimization of TCM diminutive complex prescription for lumbar inververtebral discprolapse treated by stimulating blood circulation to end stasis and diuresis and draw the best combination and ratio of various Chinese medicine.To provide scientific experiemental basis for clinical treatment.Methods：To undertake the comparative research of the best combination and ratio of various Chinese medicine by breaking the presciption,taking the comparative pharmacodynamics index as evaluating index and applying the homogeneous design.Results：By preliminary screening,to arrive at the TCM diminutive complex presciption and draw the best combination and ratio of various Chinese medicine in the prescription.The best formula and ratio are as follows：1：40g;2：30g;3：20g;4：0g;5：35g.Conclusion：The formula screening and optimization is feasible by applying prescription database;homogeneous design;combining with expertise and specific experiement result.

关 键 词：活血利水 腰椎间盘突出症 中药小复方 均匀设计 处方优化 

分 类 号：R681.53[医药卫生—骨科学]