中药牡蛎对戊巴比妥钠催眠作用的影响  

Influence of Oyster on the Hypnotic Effect of Pentobarbital Sodium in Mice

作　　者：钟洁雯[1] 陈建伟[1,2] 李祥[1,2] 蔡宝昌[1,2] 侯珂兰[1] 

机构地区：[1]南京中医药大学,江苏南京210046 [2]江苏省中药炮制重点实验室,江苏南京210029

出　　处：《中华中医药学刊》2009年第3期499-501,共3页Chinese Archives of Traditional Chinese Medicine

基　　金："十一五"国家科技支撑计划项目(2006BAI09B0604)

摘　　要：目的:观察牡蛎对小鼠戊巴比妥钠催眠作用的影响。方法:取昆明小鼠(均为雄性),随机分组,每组12只。采用不同剂量生、煅牡蛎混悬液、生牡蛎的水提液、生牡蛎中水不溶性部分及CaCO3化学药品对戊巴比妥钠诱导的小鼠睡眠时间进行镇静催眠实验研究。结果:生牡蛎混悬液、生牡蛎的水提液、生牡蛎中水不溶性部分、CaCO3化学药品及350℃下的煅牡蛎较空白对照组的睡眠时间显著延长(P<0.01)。结论:生牡蛎有较好的镇静、催眠、安神作用,低温煅制的牡蛎亦有镇静作用。Objective：To examine oyster＇ s effect of tranquilizing the central nerves system with sedative of heavy weight. Methods：Kunming mice were randomly divided into several groups （each n = 12 ）, the effects of different dose of raw, calcined oyster suspension, raw oyster liquid, the insoluble part of raw oyster liquid and CaCO3 chemistry medicine on mice pentobarbital - induced sleep hours were empirically studied. Results ：Hours of sleep prolonged in mice of raw oyster suspension, raw oyster liquid, the insoluble part of raw oyster liquid, CaCO3 chemistry medicine and calcined oysters （under 350℃） compared with ones of blank control group （ P 〈 0.01 ）. Conclusion： The oysters possess obviously sedative, hypnotic and relieving uneasiness effects. The oysters calcined under low temperature are also sedative effect.

关 键 词：牡蛎 戊巴比妥钠 催眠作用 小鼠 

分 类 号：R285.5[医药卫生—中药学]