特发性血小板减少性紫癜患者IL-2受体的变化  

Detection of interleukin2 receptor in patients withidiopathic thrombocytopenic purpura

作　　者：谭柏林[1] 尹楚兰[2] 

机构地区：[1]湖南医科大学附属湘雅医院血液科 [2]湖南医科大学附属湘雅医院同位素科

出　　处：《湖南医科大学学报》1998年第2期191-193,共3页Bulletin of Hunan Medical University

摘　　要：应用ＥＬＩＳＡ法检测ＩＴＰ患者血清可溶性白细胞介素－２受体（ＳＩＬ－２Ｒ），用间接免疫荧光法检测ＰＨＡ活化的淋巴细胞白细胞介素－２受体（ｍＩＬ－２Ｒ）。结果表明，ＩＴＰ患者糖皮质激素治疗前ＳＩＬ－２Ｒ水平升高，治疗后降低；ＰＨＡ活化的ｍＩＬ－２Ｒ数较对照组降低（Ｐ＜０．０１），且与血清ＳＩＬ－２Ｒ水平无相关性。提示ＳＩＬ－２Ｒ水平升高可能是ＩＴＰ细胞免疫功能下降的原因之一。检测血清ＳＩＬ－２Ｒ水平可作为衡量体内细胞免疫活性的一个指标。Using ELISA and indirect fluorescent antibody techniques(IFAT), the serum soluble interleukin2 receptor(sIL-2R) and membrane IL-2R(mIL2R) on lymphocyte cells induced by phytohemagglutinin (PHA) were studied in patients with idiopathic thrombocytopenic purpura(ITP). The results showed that the level of sIL-2R increased significantly before treatment and decreased after treatment; the percentages of mIL-2R induced by PHA decreased. There was no correlation between the level of serum sIL-2R and that of mIL-2R. Our observations suggest that increased level of serum sIL-2R in ITP patients may be one of causes evoking cellular immunological abnormalities.

关 键 词：紫癜 血小板减少 特发性 白细胞介素2 受体 

分 类 号：R554.602[医药卫生—血液循环系统疾病]