6例高甲胎蛋白慢乙肝患者用干扰素治疗的随访分析  

Analyses on Following up in patients With Markedly high AFP

作　　者：李国钦[1] 

机构地区：[1]北海市人民医院,广西北海536000

出　　处：《临床肝胆病杂志》2009年第2期105-106,共2页Journal of Clinical Hepatology

摘　　要：目的了解慢性乙型肝炎AFP升高患者的转归。方法对6例极高AFP患者进行抗病毒治疗,主要用重组人干扰素α1b及护肝治疗。随访(3～7)年。结果6例慢肝患者的AFP分别为1096ng/ml,1600ng/ml,4111ng/ml,1846ng/ml,1096ng/ml,1135ng/ml。住院及出院随访期间,AFP等实验室指标逐渐降至正常或接近正常。影象学检查未发现肝脏有占位性病变。结论AFP异常升高提示肝细胞过度增生,有转变为肝细胞癌的危险。干扰素抑制肝细胞过度增生,有阻断转变为肝细胞癌的效果。Objective To investigate conversion of elevated AFP in patients with chronic hepatitis B. Methods Antiviral therapy （with human interferon）was mainly used in six patients with markedly high AFP. And it was followed up for three to seven years. Results The levels of AFP and other marks were measured during duration of hospital stay and follow - up. The result shows that the levels decreased gradually to be normal and no space occupying lesion was found with imaging examination. Conclusion It suggested AFP elevated abnormally was owing to the hyperplasia of hepatocyte cell, and had higher risk of canceration. Using interferon may inhibit the hyperplasia of hepatocyte and block the canceration.

关 键 词：甲胎蛋白 干扰素 肝细胞癌 

分 类 号：R512.62[医药卫生—内科学]