乳腺癌患者接受术后辅助化疗的影响因素分析  

Analysis of influencing factors for postoperative adjuvant chemotherapy effects in elderly patients with breast cancer

作　　者：马传栋[1] 陈小松[1] 柳光宇[1] 狄根红[1] 吴炅[1] 陆劲松[1] 杨文涛[2] 韩企夏[1] 邵志敏[1] 沈镇宙[1] 沈坤炜[1] 

机构地区：[1]复旦大学上海医学院肿瘤学系复旦大学附属肿瘤医院乳腺外科,200032 [2]复旦大学上海医学院肿瘤学系复旦大学附属肿瘤医院病理科,200032

出　　处：《中华老年医学杂志》2009年第4期290-293,共4页Chinese Journal of Geriatrics

摘　　要：目的探讨65岁以上乳腺癌患者接受术后辅助化疗的影响因素。方法采用x^2检验和Logistic回归分析方法对590例6j岁以上浸润性乳腺癌患者术后辅助化疗的影响因素进行分析。结果全组接受术后辅助化疗者231例．占39．15％。结果表明，并存糖尿病、年龄、手术方式及肿瘤的病理生物学特征对患者接受术后辅助化疗有影响（x^2值分别为4．49、88．27、23．49及9．40，均为P〈0．05）。Logistic回归分析结果显示．年龄、术后病理肿瘤最大径（pT）、术后病理淋巴结状况（pN）、雌激素受体（ER）对接受术后辅助化疗有影Ⅱ向（x^2值分别为68．857、15．284、43．540、7．009，均为P〈0．01）。淋巴结阳性激素受体阴性的患者中44例（66．7％）接受了术后辅助化疗。结论肿瘤大小、淋巴结状况、激素受体状况和年龄是老年乳腺癌患者接受术后辅助化疗的独立预测因素。Objective To explore the influencing factors for postoperative adjuvant chemotherapy effects in elderly patients with breast cancer. Methods Five hundred and ninety female patients aged 65 years or older with invasive breast cancer were treated in our hospital, and the influencing factors for postoperative adjuvant chemotherapy effects were analyzed by chi-square test and logistic regression. Results Two hundred and thirty-one （39.2%） patients received postoperative adjuvant chemotherapy. The results showed that diabetes, age, patterns of operation and pathological characteristics of tumor had significant influences on postoperative adjuvant chemotherapy effects（x^2=4.49,88.27,23.49 and 9.40, all P〈0. 05）. Logistic regression analysis showed that age, tumor size, lymph node status（pN） and estrogen receptor （ER） status were related to postoperative adjuvant chemotherapy effects（x^2=68. 857,15. 284,43. 540 and 7. 009 ,all P〈0.01）. Forty-four patients （66.7%） with pN（＋）/ER（-） received adjuvant chemotherapy. Conclusions Age, tumor size, lymph node status and ER status were independent predictive factors for postoperative adjuvant chemotherapy effects in elderly patients with breast cancer.

关 键 词：乳腺癌 患者 术后 化学疗法 

分 类 号：R686[医药卫生—骨科学]