整合素β_3在子宫内膜异位症与子宫内膜癌中的表达及生物学行为相关性研究  

Expression of beta3 integrin in human endometriosis and endometrial carcinoma and correlation with biological behavior

作　　者：范佳颖[1] 叶明[1] 

机构地区：[1]广州市妇婴医院妇产科,510180

出　　处：《中国优生与遗传杂志》2009年第4期11-12,F0004,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的研究整合素β3(beta3 integrin)在子宫内膜异位症、子宫内膜癌中的表达,探讨其表达与子宫内膜异位症发生及子宫内膜异位症和子宫内膜癌生物学行为的相关性。方法采用免疫组织化学方法检测10例子宫内膜异位症在位内膜、异位内膜,10例子宫内膜癌,10例对照组正常子宫内膜整合素β3的表达。结果整合素β3在子宫内膜异位症在位内膜组的表达显著低于对照组(P<0.05),在异位内膜组中的表达显著高于在位内膜组及对照组(P<0.05、P<0.05);整合素β3在子宫内膜癌组中的表达显著高于对照组(P<0.05);整合素β3在子宫内膜异位症异位内膜组中的表达与子宫内膜癌组中的表达差异无显著性(P>0.05)。结论整合素β3的异常表达可能与子宫内膜异位症的发生有关;且可能与子宫内膜异位症具有和子宫内膜癌相似的生物学行为有关。Objective ： To study the expression of beta3 integrin in human endometriosis and endometrial carcinoma and to explore the correlation between the expression and pathogenesis of human endometriosis and their biological behavior. Methods ： Immunohisto- chemical SP method was employed to detect the expression of beta3 integrin in 10 specimens of eutopic endometrium and ectopic endometrium of endometriosis, 10 specimens of endometrial carcinoma and 10 specimens of normal endometrium. Results ： The expression of beta3 integrin in eutopic endometrium of endometriosis were significantly lowerer than normal endometrium （ P 〈 0. 05）, the expression in ectopic endometrium of endometriosis were significantly higher than those of eutopic endometrium and normal endometrium （ P 〈 0. 05, P 〈 0.05）, and the expression in endometrial carcinoma were significantly higher than those of normal endometrium （ P 〈 0. 05 ）. There was no significant difference between the expression of beta3 integrin in ectopic endometrium of human endometriosis and endometrial carcinoma （ P 〉 0.05 ）. Conclusion： The abnormal expression of beta3 integrin might be correlation with the pathogenesis of human endometriosis and the similar biological behavior between human endometriosis and endometrial carcinoma.

关 键 词：子宫内膜异位症 子宫内膜癌 整合素Β3 免疫组织化学 

分 类 号：R711.71[医药卫生—妇产科学] R737.33[医药卫生—临床医学]