缺铁性贫血和巨幼细胞贫血患者红细胞免疫功能的变化及其临床意义  

Changes of erythrocytic immune function in patients with iron deficiency anemia or megaloblastic anemia and its clinical significance

作　　者：许利民[1] 洪淋[1] 张书模[1] 冯江[1] 张荷[1] 王劲[1] 梁德佳 

机构地区：[1]第三军医大学附属大坪医院血液内科

出　　处：《第三军医大学学报》1998年第2期152-154,共3页Journal of Third Military Medical University

摘　　要：目的：探讨缺铁性贫血（ＩＤＡ）和巨幼细胞贫血（ＭＡ）患者红细胞免疫功能的变化及其临床意义。方法：采用红细胞酵母菌花环试验检测了２６例ＩＤＡ和１４例ＭＡ患者红细胞免疫功能。结果：红细胞Ｃ３ｂ受体花环率（ＲＣＲ）及红细胞促中性粒细胞吞噬率（ＥＲＰＭ）显著下降，红细胞免疫复合物花环率（ＲＩＣＲ）、红细胞Ｃ３ｂ受体花环抑制率（ＲＦＩＲ）及红细胞Ｃ３ｂ受体花环增强率（ＲＦＥＲ）无明显改变，铁剂、叶酸及维生素Ｂ１２治疗２～３个月后，ＲＣＲ和ＥＲＰＮ恢复正常。结论：ＩＤＡ和ＭＡ患者存在可逆性的红细胞免疫功能损害。Objective: To explore the changes of erythrocytic immune function in patients with iron deficiency anemia (IDA) or megaloblastic anemia (MA) and its clinical significance. Methods: The erythrocytic immune function in 26 patients with IDA and 14 with MA was observed with erythrocytic yeast rosette test. Results: The red cell C3b rosette rate (RCR) and enhancing rosette rate of phygocytosis of red cells on neutrophils (ERPN) were significantly decreased while no significant changes were found in the red cell immune complex rosette rate (RICR), red cell C3b receptor flower inhibiting rate (RFIR). RCR and ERPN were restored to normal 2～3 months after the treatment with iron preparation, folate and vitamin B12. Conclusion: There are reversible damages of the erythrocytic immune function in patients with IDA or MA.

关 键 词：缺铁性贫血 巨幼细胞 红细胞免疫功能 

分 类 号：R556.304[医药卫生—血液循环系统疾病] R446.63[医药卫生—内科学]