脑活素致85例不良反应文献分析  

Review of Literature about ADRs to Cerebrolysin in 85 Cases

作　　者：秦娜[1] 张云芳[1] 王锦爱[1] 

机构地区：[1]河南省洛阳正骨医院,洛阳471002

出　　处：《中国药事》2009年第4期406-408,共3页Chinese Pharmaceutical Affairs

摘　　要：目的探讨脑活素不良反应的特点和预防方法。方法检索1994年～2007年国内医药学期刊报道的脑活素不良反应的案例,进行统计、分析。结果脑活素所致不良反应主要发生在男性中老年患者;连续用药2次以上发生不良反应较多;临床表现复杂多样,主要表现为过敏反应,严重者可出现过敏性休克、癫痫样抽搐和类白血病反应并多器官功能障碍。结论临床医师、药师应重视脑活素的不良反应,坚持合理用药。Objective To study the characteristics and preventive measures of the adverse drug reaction （ADR） associated with Cerebrolysin. Methods ADR to Cerebrolysin in 85 cases, reported in domestic med- ical journals from 1994-2007, were collected and analysed. Results The ADR to Cerehrolysin happened in middle and old male patients. 54. 12% of ADR occurred at a second time or repeated injection. The clinical manifestations of ADR were varying, of which the allergic reaction was the frequent, and the severe ADR include anaphylactic shock, epileptoid convulsion and leukemoid reaction with multiple organ dysfunction. Conclusions Clinical physicians and pharmacists should pay attention to the ADR of Cerebrolysin and rationally use the drug.

关 键 词：脑活素 不良反应 文献分析 

分 类 号：R994.11[医药卫生—毒理学]