糖尿病足感染患者病原菌分布及耐药性分析  

Distribution and antibiotic resistance of pathogens in diabetic foot infection

作　　者：冯书红[1] 王鹏华[1] 褚月颉[1] 李代清[1] 宋振强[1] 李雪梅[1] 高芳[1] 李敏[1] 

机构地区：[1]天津医科大学代谢病医院足病科,卫生部及天津市激素与发育重点实验室,300070

出　　处：《中国糖尿病杂志》2009年第4期293-295,共3页Chinese Journal of Diabetes

摘　　要：目的探讨本院糖尿病足感染(DFI)患者病原菌及耐药性特点。方法分析2005年1月至2007年12月本院408例DFI患者足创面分离的478株病原菌及其耐药性。结果 DFI以革兰阳性菌为主(54.8%),其次是革兰阴性菌(42.1%)和真菌(3.1%)。3年中金黄色葡萄球菌感染比率呈上升趋势,铜绿假单胞菌呈下降趋势,耐药菌株比率呈逐年下降趋势(P均<0.01);多重耐药株分离率高,并检出42株耐甲氧西林金黄色葡萄球菌。结论 DFI以条件致病菌为主,多重耐药现象普遍存在,对DFI病原菌及其耐药性进行监测,可为DFI防治提供依据。Objective To investigate distribution and antibiotic resistance of pathogens isolated from the patients with diabetic foot infection （DFI） wounds in Tianjin Metabolic Hospital. Methods A retrospective study was carried out on the distribution and resistance rates of 478 bacteria strains isolated from the wounds of 408 DFI from Jan 2005 to Dec 2007. Results Gram-positive bacteria （54.8%）, gram-negative bacteria（42.1%）and fungi（3.1%）were prevalent in the DFI. During the three years, the detection rate of Staphylococcus aureus （SA） was increasing （P 〈 0. 01 ）, Pseudomonas aeruginosa was decreasing（all P〈0.01）. Antibiotic-resistant pathogens consistently decreased during the years（P〈 0. 01）. The detection rate of multidrug-resistant pathogens, including 42 methicillin-resistant SA（MRSA） strains, was high. Conclusions Opportunistic pathogens are predominant in DFI. Multidrug resistance is a common phenomenon. It is important to survey pathogens and their antibiotic resistance in DFI.

关 键 词：糖尿病足 感染 病原菌 多重耐药 

分 类 号：R587.2[医药卫生—内分泌] R446.5[医药卫生—内科学]