新的三唑类化合物体外抗真菌活性及构效关系  

In vitro antifungal activities of new synthetic triazoles and their structureactivity relationships

作　　者：周有骏[1,2] 朱驹 张万年 李科 吕加国 顾美芳[1,2] 

机构地区：[1]第二军医大学药学院药物化学教研室 [2]第二军医大学长海医院真菌室

出　　处：《第二军医大学学报》1998年第2期153-155,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金

摘　　要：目的：研究１－［２－（取代苯基）－２－（取代苯基甲硫基）乙基］－１Ｈ－１，２，４－三唑类化合物体外抗真菌活性，并初步探讨其构效关系。方法：选择８种临床致病真菌为试验菌，观察本类化合物对它们的体外抑菌活性。结果：所有化合物对８种试验菌的抑菌活性均优于或相当于氟康唑，大部分化合物的抑菌活性与硫康唑相当或更优。结论：本类化合物具有较强的广谱抗真菌活性，为深入开展广谱抗真菌药研究提供一条途径。Objective: To study the antifungal activities of 1[2 (substitutedphenyl)2[[(substitutedphenyl)methyl]thio]ethyl]1H1,2,4triazoles in vitro and discuss their structureactivity relationships.Methods and Results: The antifungal activities of the title compounds against 8 pathogenetic fungi were tested in vitro.The results showed that the antifungal activities of all title compounds were better than or comparable to that of fluconazole and the antifungal activities of most compounds were better than or comparable to that of sulconazole. Conclusion: The title compounds have broadspectrum antifungal activities and provide a route for the further study of the broadspectrum antimycotics.

关 键 词：三唑类 抗真菌剂 构效关系 

分 类 号：R978.5[医药卫生—药品]