盐酸丁卡因注射液稳定性分析  

Research on the stability of tetracaine hydrochloride injection

作　　者：张立成[1] 陈晶[1] 何艳萍[1] 

机构地区：[1]宁夏医科大学附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2009年第4期349-350,共2页Ningxia Medical Journal

基　　金：宁夏自治区科技攻关项目200769

摘　　要：目的通过对不同工艺配制的盐酸丁卡因注射液的长期考察,遴选药品稳定性较高的配制工艺。方法配制7种pH盐酸丁卡因的溶液,采取2种灭菌方式,配合2种储存条件进行注射液含量的长期考察。结果配制盐酸丁卡因注射液pH控制在4.2-4.6之间,灭菌温度为115℃25min即可,两种储存条件均可。结论满足以上3种条件后,盐酸丁卡因注射液的稳定性有长足的提高,可以延长药品的有效期。Objective To optimize the good process of tetracaine hydrochloride injection by long observation of several different preparations. Methods To observe variations of seven kinds of prepared solution of tetracaine hydrochloride injection sterilized by two methods and stored in two contions. Results The optimum technical conditions ： PH 4.2 - 4.6, 115℃, 25min for sterilized conditions. Conclusion The stability of tetracaine hydroehloride injection is improved under the two above mentioned condition. Its valid period is extended.

关 键 词：盐酸丁卡因 稳定性 

分 类 号：R927[医药卫生—药学]