^(99m)Tc研究胃漂浮片试验的安全性和影响因素  

Studies on safety and effecting factors of floating tablets in stomach with ^(99m)Tc

作　　者：刘福强[1] 车延志[1] 孙丹[2] 赵惠莹[3] 

机构地区：[1]中国人民解放军第208医院,吉林长春130062 [2]空军航空大学,吉林长春130062 [3]延边大学药学院,吉林延吉133000

出　　处：《药学实践杂志》2009年第2期104-106,110,共4页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金资助项目(30672672)

摘　　要：目的:研究漂浮片胃内同位素示踪方法,探讨安全性及影响胃内滞留因素。方法:利用ECT技术,在片剂原料中加99mTc标记,检测胃内标记物的影像,追踪肠、尿、粪便中同位素残留量。结果:胃中影像清晰;48 h后志愿者排泄物已查不出放射性同位素;饱食可延长漂浮片在胃中滞留时间。结论:漂浮片可用99mTc示踪,ECT采集影像,只要控制同位素总量本法是安全的。胃中食物是影响漂浮片在胃中滞留的主要因素。Objective： To study the method of tracing the floating tablet with isotope in the stomach and discuss the security and the influence factors to the floating tablet detained in the stomach. Methods：The ^99mTc as the sign was added to the raw material of tablet by ECT. The images in the stomach were checked and the residual quantity of isotope in intestine, urine and excrement was traced. Results：The image of tablet in the stomach was clear. The radioactivity can not traced in excreta of volunteer 48 h later. After meal, the detained time of floating in stomach can be prolonged. Conclusion：The floating tablets could be traced with ^99mTc and collected the images with ECT. It is safe if only control the total of isotope. The major factor of affecting the detained time of the floating tablets is the food in the stomach.

关 键 词：漂浮片 同位示踪 安全性 

分 类 号：R944[医药卫生—药剂学]