Synthesis, Structural Investigations and Biological Screening of Diorganotin(IV) Complexes Derived from 5,5-Diethyl Sodium Barbital  

作　　者：Wajid Rehman Amin Badshah Salimullah Khan Iftikhar Ahmad 

机构地区：[1]Department of Chemistry, Hazara University [2]Department of Chemistry, Quaid-e-Azam University [3]Department of Pharmacy, Hazara University [4]Department of Physics, Louisiana State University

出　　处：《Chinese Journal of Structural Chemistry》2009年第4期419-426,共8页结构化学（英文）

摘　　要：Some biologically important tin（Ⅳ） complexes derived from 5,5-diethyl sodium barbital have been synthesized and characterized through various analytical and spectroscopic techniques such as IR, ^1H-, ^13C-NMR and ^119mSn mossbauer. On the basis of these spectroscopic techniques, octahedral geometry has been assigned to all the novel compounds. These complexes, soluble in DMSO and DMF, were screened against a wide range of microorganisms. The results proved that the diphenyltin（Ⅳ） and dibutyltin（Ⅳ） complexes exhibit excellent activity against all types of microorganisms, while the rest of the compounds show significant activity that can be used during the biological study.Some biologically important tin（Ⅳ） complexes derived from 5,5-diethyl sodium barbital have been synthesized and characterized through various analytical and spectroscopic techniques such as IR, ^1H-, ^13C-NMR and ^119mSn mossbauer. On the basis of these spectroscopic techniques, octahedral geometry has been assigned to all the novel compounds. These complexes, soluble in DMSO and DMF, were screened against a wide range of microorganisms. The results proved that the diphenyltin（Ⅳ） and dibutyltin（Ⅳ） complexes exhibit excellent activity against all types of microorganisms, while the rest of the compounds show significant activity that can be used during the biological study.

关 键 词：5 5-diethyl sodium barbital spectra antibacterial ANTI-INFLAMMATORY ORGANOTIN 

分 类 号：O621.3[理学—有机化学]