急性有机磷农药中毒患者肝功能及血脂变化的临床观察  

Changes of serum hepatic function in patients with acute organophophorus pesticide poisoning

作　　者：郑吉顺[1] 彭琼[1] 王金华[1] 

机构地区：[1]合肥市第一人民医院消化科,安徽合肥230061

出　　处：《海南医学院学报》2009年第5期455-457,共3页Journal of Hainan Medical University

摘　　要：目的:探讨有机磷农药中毒患者肝功能、血脂变化与中毒程度的关系。方法:急性有机磷农药中毒患者54例,轻、中、重度毒各18例,中毒24 h内抽取静脉血,采用7600日立全自动化分析仪检测并比较轻、中、重度中毒患者血清中碱性磷酸酯酶(AKP)、谷氨酰转移酶(GGT)、白蛋白(ALB)、总胆固醇(TC)、甘油三酯(TG)、前白蛋白(PAB)、总胆红素(TB IL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)的水平。结果:随着中毒程度加重血清TB IL、ALT、AST明显升高(P<0.01),PAB、TC、TG明显降低(P<0.01),重度中毒组变化最明显,组间比较差异具有统计学意义(P<0.01);ALB、AKP、GGT随中毒程度变化不明显,组间比较差异无统计学意义(P>0.05)。结论:血清肝功能及血脂指标的变化有助于判断有机磷农药中毒程度,评估患者预后,对早期有效护肝治疗意义重大。Objective： To study therelationship of hepatic function, lipid and the degree of poisoning in patients with organophosphorus pesticide poisoning. Methods： Patients were divided into three groups according to the severity of intoxication：the mild, moderate and severe groups（n = 18）. Blood samples were taken for the meas- urement of serum hepatic function within 24 hours after intoxication, including alkaline phosphatase （AKP） , amin- oacyhransferase （ GGT）, albumin （ALB） , total cholesterol （ TC ） , triglyceride （ TG）, prealbumin （PAB） , total bilirubin（TBIL） , glutamate-pyruvate transaminase（GPT） and aspartate aminotransferase（AST）. Results： The severer the intoxication was, the more obviously the level of ALT, AST and TBIL increased （P 〈 0.01 ）, the more obviously the level of TC, TG and PAB decreased （P 〈 0.01 ）. The severe group changed the most obviously. The difference between groups was significantly （P 〈 0.01 ）. ALB, AKP and GGT changed inobviously in three groups （P 〉 0.05）. Conclusions： Hepatic function and lipid were helpful to judge the degree of poisoning,prognosis of patients and early protection of hepatic function.

关 键 词：有机磷农药 中毒 肝功能 血脂 

分 类 号：R595.4[医药卫生—内科学] R979.9[医药卫生—临床医学]