肿瘤相关基因rassf1a在肾细胞癌及癌旁肾组织中的表达  

Expression of tumor-related gene rassf1a in renal cell carcinoma and its adjacent tissue

作　　者：史立新[1] 李钢[1] 张磊[1] 符伟军[1] 丛冰[1] 洪宝发[1] 那彦群[2] 

机构地区：[1]解放军总医院泌尿外科,北京100853 [2]北京大学第一医院泌尿外科,北京100034

出　　处：《军医进修学院学报》2009年第2期203-205,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的:探讨肾癌、癌旁肾组织中肿瘤相关基因rassf1a的表达水平及差异及与临床分期的关系。方法:应用实时荧光定量PCR方法检测rassf1a基因在30例肾细胞癌组织及癌旁肾组织中的表达,并比较不同临床阶段其表达的差异。结果:rassf1a基因在肾癌组织中平均表达明显低于在癌旁肾组织中的平均表达。rassf1a基因在肾癌组织中的表达降低与临床分期无关。结论:肾癌的发生、发展可能与rassf1a基因有关。Objective： To investigate the different expression levels of gene rassfl a in renal carcinoma tissue and adjacent renal tissue samples and their relation with clinical staging of renal carcinoma. Methods： Real-time fluorescence quantitative PCR was performed to detect the expression levels of rassfla in 30 renal carcinoma tissue andadjacent renal tissue samples. Dif- ferent rassfl a expression levels in different clinical stages of renal carcinoma were compared. Results： The expression level of rassfl a in renal cell carcinoma tissue samples was obviously lower than that in adjacent renal tissue samples （ P 〈 0.05 ）. The lower expression level of rassfl a in renal cell carcinoma tissue samples was not related with the clinical staging of renal carcinoma. Conclusion： Rassfl a gene might be related to the occurrence and progression of renal carcinoma.

关 键 词：肾肿瘤 基因 RASSFLA 

分 类 号：R349.64[医药卫生—基础医学] R737.11