电磁辐射对小鼠免疫功能的抑制作用  

Inhibitory effect of electromagnetic radiation on immune function of mice

作　　者：孟旭英[1] 高春记[1] 张怡堃[2] 陈卫华[1] 苏镇涛[3] 周红梅[3] 

机构地区：[1]解放军总医院血液科,北京100853 [2]第二炮兵总医院,北京100088 [3]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《军医进修学院学报》2009年第2期215-217,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的:研究电磁辐射对小鼠免疫功能的影响。方法:288只BALB/c小鼠随机分为4组,分别接受频率为2856MHZ、辐射剂量依次为0mW/cm2、5mW/cm2、10mW/cm2、20mW/cm2的辐射,辐射时间均为10min×6/d,连续照射5d。于照射后1h、1d、3d、7d、15d、30d检测外周血细胞计数、外周血T细胞亚群(CD4、CD8)、胸腺指数。结果:照射组在所有检测时间点与对照组(0mW/cm2)相比白细胞计数及淋巴细胞计数均下降、CD4+/CD8+比值升高、胸腺指数下降(P<0.05),至检测后期差异尤为显著,且免疫抑制作用随照射剂量增大而增强。结论:电磁辐射能抑制小鼠的免疫功能,且随着功率密度增大而抑制作用增强。Objective： To study the effect of electromagnetic radiation on immune function of mice. Methods ： Two hundred and eighty-eight BALB/c mice were randomly divided into four groups, which were exposed to 2 856 MHz electromagnetic radiation at the power density of 0mW/cm^2, 5mW/cm^2 , 10mW/cm^2 and 20mW/cm^2 , respectively, I h a day, for 5 consecutive days. The number of peripheral blood cells, the distribution of T-cell subpopulations （ CD4 and CD8 ） , and thymus index were detected 1h, 1 d, 3d, 7d, 15d, and 30d, respectively, after electromagnetic radiation. Results： The number of leukocytes, lvmphocytes and thymus index was significantly decreased ＇after electromagnetic radiation at any time point, while the CD4^＋/CD8^＋ ratio was increased （P 〈 0.05 ）. These abnormalities aggravated gradually with time during the study. Furthermore, the inhibitory effect of electromagnetic radiation on the immune function of mice was enhanced with the increased power density of electromagnetic radiation. Conclusion： Electromagnetic radiation can suppress the immune function of mice and the suppressing effect of electromagnetic radiation on immune function of mice increases with increasing power densities.

关 键 词：辐射 淋巴细胞 免疫 

分 类 号：R818[医药卫生—放射医学]