脑梗死患者同型半胱氨酸水平与血小板聚集功能关系探讨  

The Investigation of Homocysteine Levels and Platelet Aggregation in Patients with Acute Cerebral Infarction

作　　者：张云平[1] 辛晓敏[1] 毕莉[1] 

机构地区：[1]哈尔滨医科大学第一附属临床医学院检验科,黑龙江哈尔滨150001

出　　处：《中国血液流变学杂志》2009年第1期103-105,共3页Chinese Journal of Hemorheology

基　　金：黑龙江省教育厅支持项目（11531203）

摘　　要：目的探讨脑梗死患者同型半胱氨酸水平（Homocysteine，HCY）与血小板聚集功能之间的关系。方法检测117例脑梗死患者及91名健康体检者的HCY及以二磷酸腺苷（ADP）和花生四烯酸（AA）为诱导剂的血小板聚集功能，进行统计对比分析。结果脑梗死组的HCY水平和血小板聚集功能与对照组比较有显著差异（P〈0．05）高HCY患者组的血小板聚集功能与正常HCY患者组比较有显著差异（P〈0．05）。结论HCY水平增高可引起血小板聚集功能增强，是脑梗死再发高危险因素。Objective To investigate the relationship between homocysteine （HCY）levels and platelet aggregation in patients with acute cerebral infarction （ACI）.Methods 117 cases with acute cerebral infarction and 91 healthy controls were obtained for examining Hcy and platelet aggregation induced by adenosine diphosphate（ADP） and Arachidonic Acid （AA）.Resuits Hey levels and platelet aggregation in ACI group were significantly higher than those of normal controls（P〈0.05）.Platelet aggregation was different between the cerebral infarction patients with hyperhomocysteine and the cerebral infarction patients with normal homocysteine（P〈0.05）. Conclusion Hyperho- mocysteine may lead to the increase of platelet aggregation, which is one of the important risk reasons for recurrence of the cerebral infarction.

关 键 词：脑梗死 同型半胱氨酸 血小板聚集 

分 类 号：R446.1[医药卫生—诊断学] R743[医药卫生—临床医学]