磁共振波谱对特发性震颤的病因学观察  

MRS observation on etiology of essential tremor

作　　者：刘佳[1] 沈加林[1] 许建荣[1] 周滟[1] 路青[1] 

机构地区：[1]上海交通大学医学院附属仁济医院放射科,上海200127

出　　处：《中国医学影像技术》2009年第3期366-368,共3页Chinese Journal of Medical Imaging Technology

摘　　要：目的用磁共振波谱(MRS)观察特发性震颤(ET)患者小脑皮质代谢物变化情况。方法ET患者11例为病例组,健康人7名为对照组,对双侧小脑皮质进行磁共振波谱(MRS)检查,计算乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)比值,并对每例患者进行临床评分(Fahn-Tolosa-Marin)。结果病例组同侧小脑皮质NAA/Cr较对照组减低(0.78±0.05,0.90±0.16;P=0.03)。病例组双侧小脑皮质代谢物比值与症状评分间无明显相关性。结论ET患者小脑皮质存在神经元的损伤或丢失,提示ET很可能是一种神经退行性疾病。Objective To investigate the metabolic alterations in the cerebellar cortex of patients with essential tremor （ET） using magnetic resonance spectroscopy （MRS）. Methods Eleven ET patients and 7 healthy controls underwent ^1H-MRS examination to measure levels of intraeellular metabolites, including ratio of N-acetyll-aspartate （NAA） and total choline （Cho） to total creatine （Cr） in cerebellar cortex with a 3.0T Philips Achieva System. Results The mean （standard deviation） ipsilateral cerebellar cortical NAA/Cr decreased in ET patients compared with controls （0.78±0.05 vs 0.90±0.16, P=0.03）. There was no relationship between eerebellar cortical NAA/Cr and dominant arm tremor severity （P〉0.05）. Conclusion The reduction in cerebellar cortical NAA/Cr indicates that there is neuronal damage or loss in ET, suggesting that ET may be a neurodegenerative disease.

关 键 词：特发性震颤 磁共振波谱 小脑皮质 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742[医药卫生—诊断学]