蝙蝠脑血流的磁共振脑灌注成像测量  

Noninvasive cerebral blood flow mapping of bats with magnetic resonance perfusion imaging

作　　者：蒙宇光[1,2] 胡开良[3] 雷皓[1] 

机构地区：[1]中国科学院武汉物理与数学研究所、波谱与原子分子物理国家重点实验室,湖北武汉430071 [2]中国科学院研究生院,北京100049 [3]华东师范大学生命科学学院,上海200062

出　　处：《中国医学影像技术》2009年第4期571-573,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(10234070)

摘　　要：目的建立一种能定量测量蝙蝠脑血流(CBF)的连续动脉血标记磁共振灌注成像方法。方法采用spiral快采样方式以降低磁场不均匀性对成像结果的影响,并同时提高CBF测量的时间分辨率。以所建立的方法测量棕果蝠和几内亚长翼蝠的脑血流。结果在异氟醚麻醉下,棕果蝠丘脑和皮层的脑血流分别为(1.51±0.21)ml/(min.g)和(0.75±0.29)ml/(min.g);而几内亚长翼蝠丘脑和皮层的脑血流分别为(2.30±0.36)ml/(min.g)和(1.17±0.17)ml/(min.g)。结论蝙蝠丘脑和皮层中局部脑血流的不同可能反应了麻醉状态下这两个脑区中代谢水平的高低。Objective To establish a magnetic resonance perfusion imaging method for quantitatively measuring cerebral blood flow （CBF） in bats. Methods Continuous arterial spin labeling technique was used to produce CBF-weighted signals, and a fast imaging technique with spiral sampling trajectory were employed as the read-out to reduce the effects of magnetic field inhomogeneities and to improve the temporal resolution of CBF measurements. The method was applied to CBF meas- urements in two species of bats from two different suborders, Rousettus leschenaulti and Miniopterus magnater. Results Under isoflurane-anesthesia, CBF in the thalamus and cortex were found to be （1.51±0. 21） and （0. 75±0. 29）ml/（min·g） for the macrobat, and （2. 30±0.36） and （1.17±0. 17）ml/（min·g） for the microbat. Conclusion The significant regional CBF difference may be manifestation of the different functional/metabolic levels in these two brain regions. The perfusion imaging method established should serve as a useful tool for functional imaging and protection of bats （especially for the rare and pre- cious species）.

关 键 词：脑血流 灌注 动脉血自旋标记 磁共振成像 蝙蝠 

分 类 号：R445.2[医药卫生—影像医学与核医学] R-332[医药卫生—诊断学]