Gender and metabolic differences of gallstone diseases  

作　　者：Hui Sun Hong Tang Shan Jiang Li Zeng En-Qiang Chen Tao-You Zhou You-Juan Wang 

机构地区：[1]Center of Infectious Diseases, West China Hospital of SichuanUniversity Division of Molecular Biology of Infectious Diseases,the State Key Laboratory of Biotherapy (Sichuan University),Chengdu 610041, Sichuan Province, China [2]First Department of internal Medicine, Wusheng People's Hospital, Guangan 638400, Sichuan Province, ChinaLi Zeng, You-Juan Wang, Physical Examination Center,West China Hospital of Sichuan University, Chengdu 610041,Sichuan Province, China [3]Physical Examination Center,West China Hospital of Sichuan University, Chengdu 610041,Sichuan Province, China

出　　处：《World Journal of Gastroenterology》2009年第15期1886-1891,共6页世界胃肠病学杂志（英文版）

基　　金：The National Natural Science Foundation of China,No.30571640;the National Basic Research Program of China,No.2006CB504302 and No.2007CB512902

摘　　要：AIM： To investigate the risk factors for gallstone disease in the general population of Chengdu, China. METHODS： This study was conducted at the West China Hospital. Subjects who received a physical examination at this hospital between January and December 2007 were included. Body mass index, blood pressure, fasting plasma glucose, serum lipid and lipoproteins concentrations were analyzed. Gallstone disease was diagnosed by ultrasound or on the basis of a history of cholecystectomy because of gallstone disease. Unconditional logistic regression analysis was used to investigate the risk factors for gallstone disease, and the Chi-square test was used to analyze differences in the incidence of metabolic disorders between subjects with and without gallstone disease. RESULTS： A total of 3573 people were included, 10.7% （384/3573） of whom had gallstone diseases. Multiple logistic regression analysis indicated that the incidence of gallstone disease in subjects aged 40-64 or ≥65 years was significantly different from that in those aged 18-39 years （P 〈 0.05）; the incidence was higher in women than in men （P 〈 0.05）. In men,a high level of fasting plasma glucose was obvious in gallstone disease （P 〈 0.05）, and in women, hypertriglyceridemia or obesity were significant in gallstone disease （P 〈 0.05）. CONCLUSION： We assume that age and sex are profoundly associated with the incidence of gallstone disease; the metabolic risk factors for gallstone disease were different between men and women.AIM:To investigate the risk factors for gallstone disease in the general population of Chengdu,China. METHODS:This study was conducted at the West China Hospital.Subjects who received a physical examination at this hospital between January and December 2007 were included.Body mass index,blood pressure,fasting plasma glucose,serum lipid and lipoproteins concentrations were analyzed.Gallstone disease was diagnosed by ultrasound or on the basis of a history of cholecystectomy because of gallstone disease.Unconditional logistic regression analysis was used to investigate the risk factors for gallstone disease,and the Chi-square test was used to analyze differences in the incidence of metabolic disorders between subjects with and without gallstone disease. RESULTS:A total of 3573 people were included, 10.7%(384/3573)of whom had gallstone diseases. Multiple logistic regression analysis indicated that the incidence of gallstone disease in subjects aged 40-64 or≥65 years was significantly different from that in those aged 18-39 years(P<0.05);the incidence was higher in women than in men(P<0.05).In men,a high level of fasting plasma glucose was obvious in gallstone disease(P<0.05),and in women, hypertriglyceridemia or obesity were significant in gallstone disease(P<0.05).

关 键 词：Gallstone disease Metabolic disorder Riskfactor SEX Age 

分 类 号：R58[医药卫生—内分泌] R542.22[医药卫生—内科学]