氩离子凝固术对兔大肠黏膜的损伤作用  

Mucosal injury caused by argon plasma coagulation in rabbits

作　　者：窦艳[1] 刘庆森[1] 杨云生[1] 孟江云[1] 

机构地区：[1]中国人民解放军总医院消化科,北京市100853

出　　处：《世界华人消化杂志》2009年第8期821-824,共4页World Chinese Journal of Digestology

摘　　要：目的:研究国产氩离子凝固治疗仪不同输出参数对兔大肠黏膜的损伤深度,探讨APC治疗的安全使用范围.方法:以国产氩离子凝固治疗仪对32只新西兰白兔在体大肠黏膜进行凝固,参数选用不同氩气流量(2.0、2.5、3.0、4.0L/min)和不同作用方式(3s连续方式和脉冲方式凝固).内镜超声测量结肠壁厚度,光学显微镜下观察组织损伤深度.结果:内镜超声扫描喷凝局部黏膜呈高回声,其余各层回声减低.随氩气流量和输出功率增加,大肠黏膜损伤加重(P=0.006、0.023).脉冲方式和连续方式对大肠壁的损伤程度有统计学差异(P=0.030),脉冲方式的组织损伤程度较连续方式轻.结论:氩离子凝固术对大肠黏膜损伤深度可控,可以作为一种安全的治疗手段.AIM： To investigate mucosal injury induced by argon plasma coagulation （APC） in rabbits. METHODS： The mucosal injury of large intes- tine of rabbits was induced by APC with argon gas flow 2.0, 2.5, 3.0 and 4.0 L/min in two pulsed modes. Thickness of mucosa was measured by endoscopic ultra sound （EUS）. Qualitative his- tologic analysis of each site of APC application was performed by light microscopy. RESULTS： EUS showed high echo in mucosa while low echo in submucosa and muscularis propria. Depth of injury was significantly correlated with argon gas flow （P = 0.006）, power set- ring （P = 0.023） and duration of pulse （P=0.030）. CONCLUSION： APC is a safe method in treat- ment of colon disease. The lower argon gas flow and short durations have the lowest risk of deep tissue injury.

关 键 词：氩离子凝固术 大肠 黏膜 

分 类 号：R656.7[医药卫生—外科学]